School of Chemistry, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India.
Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Dalton Trans. 2020 Aug 18;49(32):11059-11072. doi: 10.1039/d0dt02045a.
Enzymes exhibit a large degree of compatibility with metal-organic frameworks (MOFs) which allows the development of multicomponent catalysts consisting of enzymes adsorbed or occluded by MOFs. The combination of enzymes and MOFs in a multicomponent catalyst can be used to promote cascade reactions in which two or more individual reactions are performed in a single step. Cascade reactions take place due to the cooperation of active sites present on the MOF with the enzyme. A survey of the available data establishes that often an enzyme undergoes stabilization by association with a MOF and the system exhibits notable recyclability. In addition, the existence of synergism is observed as a consequence of the close proximity of all the required active sites in the multicomponent catalyst. After an introductory section describing the specific features and properties of enzyme-MOF assemblies, the main part of the present review focuses on the description of the cascade reactions that have been reported with commercial enzymes associated with MOFs, paying special attention to the advantages derived from the multicomponent catalyst. Related to the catalytic activity to metabolize glucose, generating reactive oxygen species (ROS) and decreasing the solution pH, an independent section describes the recent use of enzyme-MOF catalysts in cancer therapy. The last paragraphs summarize the current state of the art and provide our view on future developments in this field.
酶与金属有机骨架（MOFs）表现出很大的兼容性，这使得由吸附或包含在 MOFs 中的酶组成的多组分催化剂的发展成为可能。多组分催化剂中酶和 MOFs 的结合可用于促进级联反应，其中两个或更多个单独的反应在单个步骤中进行。级联反应是由于 MOF 上存在的活性位点与酶的协同作用而发生的。对现有数据的调查表明，通常酶通过与 MOF 结合而稳定，并且该系统表现出显著的可回收性。此外，由于多组分催化剂中所有必需的活性位点非常接近，因此观察到协同作用的存在。在描述酶-MOF 组装体的特定特征和性质的介绍性部分之后，本综述的主要部分重点描述了与 MOFs 相关的商业酶报告的级联反应，特别关注多组分催化剂带来的优势。与代谢葡萄糖、生成活性氧物种（ROS）和降低溶液 pH 值的催化活性有关，独立的部分描述了酶-MOF 催化剂在癌症治疗中的最新用途。最后几段总结了目前的技术水平，并提供了我们对该领域未来发展的看法。
