Department of Geriatrics Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, M. Curie-Skłodowskiej Street 9, 85 - 094 Bydgoszcz, Poland.
Clinic Neurosurgery and Neurology, Stroke Care Unit, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz.
Neurol Neurochir Pol. 2020;54(5):440-448. doi: 10.5603/PJNNS.a2020.0064. Epub 2020 Aug 18.
Screening tests are a key step in the diagnosis of dementia and should therefore be highly sensitive to the detection of mild neurocognitive disorders (NCD). The Mini Mental State Examination (MMSE) is the most commonly used screening method. The Montreal Cognitive Assessment (MoCA) is a newer and less well-known screening tool, which has none of the limitations of the MMSE.
The aim of this study was to analyse the reliability of the Polish versions of MoCA 7.2 vs MMSE in the detection of mild NCD among people aged over 60.
The study was carried out at the Department and Clinic of Geriatrics from September 2014 to March 2017. The study included 281 participants, 91 of whom were assigned to the group without NCD. The other 190 had been diagnosed with mild NCD.
In the analysis of the ROC curve of the MoCA 7.2 results, the AUC was 0.925 (p < 0.001). The optimal cut-off point for mild NCD was 23/24 points, with sensitivity and specificity of 83.2% and 79.1%. In the ROC curve of MMSE results, the AUC was 0.847 (p < 0.001). The optimal cut-off point for mild NCD was 27/28 points, with sensitivity and specificity of 75.8% and 66.7%. The difference between AUC MoCA 7.2 and MMSE was 0.078 (p = 0.036).
MoCA 7.2 detects mild NCD with more sensitivity than MMSE. We recommend using the cut-off point for MoCA of 23/24 points, because this is characterised by a higher sensitivity than the previously recommended cut-off point of 25/26 points. For the MMSE, the recommended cut-off point should be 27/28, which gives greater diagnostic accuracy than the previously recommended 25/26 points.
筛查测试是痴呆诊断的关键步骤,因此应该对轻度神经认知障碍(NCD)的检测具有高度敏感性。简易精神状态检查(MMSE)是最常用的筛查方法。蒙特利尔认知评估(MoCA)是一种较新且不太知名的筛查工具,它没有 MMSE 的任何局限性。
本研究旨在分析波兰语版本的 MoCA 7.2 与 MMSE 在检测 60 岁以上人群轻度 NCD 中的可靠性。
该研究于 2014 年 9 月至 2017 年 3 月在老年病学部和诊所进行。该研究共纳入 281 名参与者,其中 91 名被分配到无 NCD 组。其余 190 名被诊断为轻度 NCD。
在 MoCA 7.2 结果的 ROC 曲线分析中,AUC 为 0.925(p < 0.001)。轻度 NCD 的最佳截断点为 23/24 分,敏感性和特异性分别为 83.2%和 79.1%。在 MMSE 结果的 ROC 曲线中,AUC 为 0.847(p < 0.001)。轻度 NCD 的最佳截断点为 27/28 分,敏感性和特异性分别为 75.8%和 66.7%。MoCA 7.2 和 MMSE 的 AUC 之间的差异为 0.078(p = 0.036)。
MoCA 7.2 比 MMSE 更敏感地检测轻度 NCD。我们建议使用 MoCA 的 23/24 分作为截断点,因为这比之前推荐的 25/26 分的截断点具有更高的敏感性。对于 MMSE,推荐的截断点应为 27/28,这比之前推荐的 25/26 分具有更高的诊断准确性。