Mental Health Center Ballerup, Maglevaenget 32, 2750, Ballerup, Denmark.
Institute for Clinical Medicine, Copenhagen University, Blegdamsvej 3B, 2200, Copenhagen, Denmark.
Psychopharmacology (Berl). 2020 Oct;237(10):2891-2903. doi: 10.1007/s00213-020-05626-5. Epub 2020 Aug 18.
The psychopathology of anorexia nervosa (AN) includes altered social cognition and information processing of fear and anxiety. Oxytocin, a neuromodulating hormone, may influence these functions and could be valuable for the treatment of AN.
The current study aimed at reviewing the effect of intranasal oxytocin (IN-OT) on attentional bias (AB) and emotion recognition (ER) in AN.
A systematic literature review was done for free-text and the MeSH-terms: anorexia nervosa, feeding and eating disorders, and oxytocin. Six publications, reporting from 4 unique clinical trials, were included in this review. A meta-analysis was conducted to examine the effects of IN-OT on AB towards food images and ER on healthy controls (HC) and patients with AN.
Overall, IN-OT did not influence AB towards food images (effect size = 0.20 [- 0.16, 0.57], p = 0.28) and had no effect on ER (effect size = - 0.01 [- 0.27, 0.26], p = 0.97) in patients with AN and healthy control (HC) subjects collectively. Assessing HC and AN separately in subgroup analyses did not show any significant effect on AB and ER in neither of the subgroups. All tests were done between 15 and 55 min post-administration of IN-OT, while peak concentration in the cerebrospinal fluid has been determined to be at 75 min.
The current level of evidence is moderate showing no effect of IN-OT on AB or ER in AN. However, brain exposure may not have been sufficient which future studies with IN-OT need to ensure by considering dose and dose-to-task interval.
神经性厌食症（AN）的精神病理学包括改变的社会认知和对恐惧和焦虑的信息处理。神经调质催产素可能会影响这些功能，并且对于治疗 AN 可能具有重要价值。
本研究旨在综述鼻内给予催产素（IN-OT）对 AN 患者的注意力偏向（AB）和情绪识别（ER）的影响。
通过自由文本和 MeSH 术语进行系统文献综述：神经性厌食症、摄食和进食障碍、催产素。本综述纳入了 6 项研究，均来自 4 项独特的临床试验。进行了荟萃分析，以检查 IN-OT 对 AN 患者和健康对照（HC）对食物图像的 AB 和对 ER 的影响。
总体而言，IN-OT 并未影响对食物图像的 AB（效应量=0.20[-0.16，0.57]，p=0.28），也未影响 AN 患者和 HC 对 ER（效应量=-0.01[-0.27，0.26]，p=0.97）的影响。在亚组分析中分别评估 HC 和 AN，在两个亚组中，AB 和 ER 均无显著影响。所有测试均在 IN-OT 给药后 15 至 55 分钟之间进行，而脑脊髓液中的峰值浓度已确定为 75 分钟。
目前的证据水平为中等，表明 IN-OT 对 AN 患者的 AB 或 ER 没有影响。但是，脑暴露可能不足，未来的 IN-OT 研究需要通过考虑剂量和剂量-任务间隔来确保。
