PRIAMO 研究：早发性帕金森病中前驱便秘与疾病表型的年龄和性别相关性。
The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.
机构信息
Department of Medicine, Surgery and Dentistry, Neuroscience Section, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, 84131, Italy.
Department of Primary Care and Public Health, School of Public Health, Imperial College of London, London, UK.
出版信息
J Neurol. 2021 Feb;268(2):448-454. doi: 10.1007/s00415-020-10156-3. Epub 2020 Aug 18.
OBJECTIVES
To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages.
METHODS
A total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).
RESULTS
As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.
CONCLUSIONS
Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson's disease may impact disease phenotype.
目的
探讨在帕金森病早期，性别和年龄对前驱便秘与疾病表型之间关系的影响。
方法
根据前驱便秘的存在情况，对 PRIAMO 研究中的 385 名帕金森病患者进行分类，并随访 24 个月。应用多变量混合效应模型。所有分析均分别针对男性（64.1%）和女性（不同性别：男性 67 岁，女性 68 岁）的中位数年龄进行。
结果
就性别而言，前驱便秘仅与女性更易出现注意力/记忆障碍和淡漠症状有关。就年龄而言，前驱便秘仅与老年患者认知功能降低和淡漠程度增加有关。
结论
在女性和老年患者中，前驱便秘预示着认知功能下降和更严重的淡漠，这是疾病的最早阶段。帕金森病前驱标志物的性别和年龄相关异质性可能影响疾病表型。
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