Université de Paris, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, "Endosomal dynamic in neuropathies", Paris, France.
INSERM U932, Institut Curie, PSL Research University, Paris, France.
EMBO J. 2020 Aug 17;39(16):e105119. doi: 10.15252/embj.2020105119. Epub 2020 Jul 28.
Extracellular vesicles mediate transfer of diverse molecular content to target cells in order to induce phenotypic changes, which has put them under the spotlight as likely major players in cell-to-cell communication. However, extracellular vesicle heterogeneity in terms of intracellular origin has only recently been recognized as a potential determinant of their activity. Recent work by Fan et al (2020) illustrates how lack of external resources that affect cellular homeostasis and signaling can also modulate EV biogenesis, by inducing the production of a novel subpopulation of exosomes enriched in Rab11a with context-dependent roles in Drosophila gland physiology and cancer cell aggressiveness.
细胞外囊泡将不同的分子内容转移到靶细胞中，以诱导表型变化，这使它们成为细胞间通讯的重要参与者。然而，细胞外囊泡在细胞内起源方面的异质性最近才被认为是其活性的一个潜在决定因素。Fan 等人（2020）的最新研究表明，缺乏影响细胞内稳态和信号转导的外部资源也可以通过诱导产生富含 Rab11a 的新型外体亚群来调节 EV 的生物发生，这种亚群在外显子水平上具有与 context-dependent 相关的功能，在果蝇腺体生理学和癌细胞侵袭性中发挥作用。
