University Artois, UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), F-62300 Lens, France.
Cells. 2021 Dec 31;11(1):133. doi: 10.3390/cells11010133.
The construction of the blood-brain barrier (BBB), which is a natural barrier for maintaining brain homeostasis, is the result of a meticulous organisation in space and time of cell-cell communication processes between the endothelial cells that carry the BBB phenotype, the brain pericytes, the glial cells (mainly the astrocytes), and the neurons. The importance of these communications for the establishment, maturation and maintenance of this unique phenotype had already been suggested in the pioneering work to identify and demonstrate the BBB. As for the history of the BBB, the evolution of analytical techniques has allowed knowledge to evolve on the cell-cell communication pathways involved, as well as on the role played by the cells constituting the neurovascular unit in the maintenance of the BBB phenotype, and more particularly the brain pericytes. This review summarises the key points of the history of the BBB, from its origin to the current knowledge of its physiology, as well as the cell-cell communication pathways identified so far during its development, maintenance, and pathophysiological alteration.
血脑屏障（BBB）的构建是维持脑内环境稳定的天然屏障，它是内皮细胞、脑周细胞、神经胶质细胞（主要是星形胶质细胞）和神经元之间细胞间通讯过程在空间和时间上的精细组织的结果。这些通讯对于建立、成熟和维持这种独特表型的重要性，在识别和证明 BBB 的开创性工作中已经得到了提示。就 BBB 的历史而言，分析技术的发展使得人们对参与的细胞间通讯途径以及构成神经血管单元的细胞在维持 BBB 表型，特别是脑周细胞中的作用的认识不断发展。这篇综述总结了 BBB 从起源到目前对其生理学的认识的历史要点，以及在其发育、维持和病理生理改变过程中迄今为止确定的细胞间通讯途径。
