The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China.
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Pharm Dev Technol. 2020 Dec;25(10):1249-1259. doi: 10.1080/10837450.2020.1810274. Epub 2020 Aug 30.
In sonodynamic therapy (SDT), when Chlorin e6 (Ce6) accumulates in tumor tissues, its anti-tumor effect can be achieved by ultrasound activation. To increase the local drug concentration of Ce6 in tumor cells, we had established a novel drug delivery system, Ce6-loaded sonosensitive magnetic nanoliposome (Ce6/SML), which realized the targeting delivery by the external magnetic field. It was worth mentioning that the targeting release of Ce6/SML and the activation on Ce6 could be achieved simultaneously by ultrasound of SDT. In our study, after Ce6 was loaded into the sonosensitive magnetic nanoliposome (SML), the values of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and were determined, indicating the activation on Ce6 of ultrasound. The delivery system also displayed the tumor-targeting ability and anti-tumor activity, which associated with the determined tumor growth and expression levels of angiogenin (ANG), vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α). In conclusion, the Ce6/SML-SDT-Targeted delivery system could effectively enhance the anti-tumor activity of SDT and had a great potential application for the treatment of malignant tumors located in deep tissues.
在声动力学疗法（SDT）中，当氯乙啶 6（Ce6）积聚在肿瘤组织中时，可以通过超声激活来实现其抗肿瘤作用。为了增加肿瘤细胞中 Ce6 的局部药物浓度，我们建立了一种新型药物递送系统，即载有 Ce6 的声敏磁性纳米脂质体（Ce6/SML），它通过外部磁场实现靶向递送。值得一提的是，Ce6/SML 的靶向释放和 SDT 中的 Ce6 激活可以同时通过超声来实现。在我们的研究中，Ce6 被加载到声敏磁性纳米脂质体（SML）中后，测定了超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的值，表明超声对 Ce6 的激活。该递送系统还表现出肿瘤靶向能力和抗肿瘤活性，这与确定的肿瘤生长和血管生成素（ANG）、血管内皮生长因子（VEGF）和肿瘤坏死因子-α（TNF-α）的表达水平有关。总之，Ce6/SML-SDT-靶向递送系统可以有效增强 SDT 的抗肿瘤活性，对于治疗位于深部组织的恶性肿瘤具有很大的潜在应用价值。
