Department of Pharmacy, Haga Teaching Hospital, Els Borst-Eilersplein 275, 2545 CH, The Hague, The Netherlands.
Department of Hospital Pharmacy, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Int J Clin Pharm. 2021 Feb;43(1):66-76. doi: 10.1007/s11096-020-01101-5. Epub 2020 Aug 19.
Background Medication errors occur frequently in intensive care units (ICU). Voluntarily reported medication errors form an easily available source of information. Objective This study aimed to characterize prescribing, monitoring and medication transfer errors that were voluntarily reported in the ICU, in order to reveal medication safety issues. Setting This retrospective data analysis study included reports of medication errors from eleven Dutch ICU's from January 2016 to December 2017. Method We used data extractions from the incident reporting systems of the participating ICU's. The reports were transferred into one database and categorized into type of error, cause, medication (groups), and patient harm. Descriptive statistics were used to calculate the proportion of medication errors and the distribution of subcategories. Based on the analysis, ICU medication safety issues were revealed. Main outcome measure The main outcome measure was the proportion of prescribing, monitoring and medication transfer error reports. Results Prescribing errors were reported most frequently (n = 233, 33%), followed by medication transfer errors (n = 85, 12%) and monitoring errors (n = 27, 4%). Other findings were: medication transfer errors frequently caused serious harm, especially the omission of home medication involving the central nervous system and proton pump inhibitors; omissions and dosing errors occurred most frequently; protocol problems caused a quarter of the medication errors; and medications needing blood level monitoring (e.g. tacrolimus, vancomycin, heparin and insulin) were frequently involved. Conclusion This analysis of voluntarily reported prescribing, monitoring and medication transfer errors warrants several improvement measures in these processes, which may help to increase medication safety in the ICU.
背景
在重症监护病房(ICU)中,药物错误经常发生。自愿报告的药物错误是一种易于获取的信息来源。
目的
本研究旨在描述 ICU 中自愿报告的处方、监测和药物转用错误,以揭示药物安全问题。
设置
本回顾性数据分析研究包括 2016 年 1 月至 2017 年 12 月来自 11 家荷兰 ICU 的药物错误报告。
方法
我们使用参与 ICU 的事件报告系统的数据提取。报告被转移到一个数据库中,并按照错误类型、原因、药物(组)和患者伤害进行分类。使用描述性统计数据计算药物错误的比例和子类别分布。基于分析,揭示了 ICU 药物安全问题。
主要结果措施
主要结果措施是处方、监测和药物转用错误报告的比例。
结果
报告最多的是处方错误(n=233,33%),其次是药物转用错误(n=85,12%)和监测错误(n=27,4%)。其他发现包括:药物转用错误经常导致严重伤害,特别是涉及中枢神经系统和质子泵抑制剂的家庭用药遗漏;遗漏和剂量错误最常发生;方案问题导致四分之一的药物错误;需要血药浓度监测的药物(如他克莫司、万古霉素、肝素和胰岛素)经常涉及。
结论
对自愿报告的处方、监测和药物转用错误的分析需要对这些过程采取几项改进措施,这可能有助于提高 ICU 的药物安全性。