Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China.
Chem Commun (Camb). 2020 Sep 22;56(75):11078-11081. doi: 10.1039/d0cc03734f.
We report a one-pot approach for the scalable synthesis of zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) using poly(ethylene glycol) as the mineralizer, where drugs and proteins can be encapsulated in the ZIF-8 NPs for intracellular delivery. The ZIF-8 NPs exhibit high colloidal dispersity and stability (above two weeks) in cell medium.
我们报告了一种使用聚乙二醇作为矿化剂的沸石咪唑酯骨架-8 纳米粒子 (ZIF-8 NPs) 的可扩展合成的一锅法，其中药物和蛋白质可以封装在 ZIF-8 NPs 中用于细胞内递药。ZIF-8 NPs 在细胞培养基中表现出高胶体分散性和稳定性（超过两周）。
