Wang J C, Giaever G N
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
Science. 1988 Apr 15;240(4850):300-4. doi: 10.1126/science.3281259.
A number of ways are known by which an event at one location on a DNA molecule can affect an event at a distant location on the same molecule. Three classes of mechanisms are described for such distal actions: tracking or translocation of a protein along a DNA, the association of two proteins bound at separate sites to form a DNA loop in between, and distal interactions that are affected by the topology of the DNA. The basic characteristics of each type of mechanism are discussed in terms of the known physicochemical properties of DNA. The various modes of action at a distance are often interrelated. Examples include the formation of positively and negatively supercoiled DNA loops by tracking and the strong effects of DNA topology on looping.
人们已经知道DNA分子上一个位置的事件能够影响同一分子上远处位置事件的多种方式。针对这种远端作用描述了三类机制：蛋白质沿DNA的追踪或易位、在分开位点结合的两种蛋白质形成其间的DNA环的关联以及受DNA拓扑结构影响的远端相互作用。根据已知的DNA物理化学性质讨论了每种机制类型的基本特征。远距离的各种作用模式常常相互关联。例子包括通过追踪形成正向和负向超螺旋DNA环以及DNA拓扑结构对成环的强烈影响。
