Department of Chemistry, Temple University, Philadelphia, PA 19122, USA.
Biomolecules. 2024 Nov 13;14(11):1442. doi: 10.3390/biom14111442.
Many DNA metabolic pathways, including DNA repair, require the transmission of signals across long stretches of DNA or between DNA molecules. Solutions to this signaling challenge involve various mechanisms: protein factors can travel between these sites, loop DNA between sites, or form oligomers that bridge the spatial gaps. This review provides an overview of how these paradigms have been used to explain DNA mismatch repair, which involves several steps that require action-at-a-distance. Here, we describe these models in detail and how current data fit into these descriptions. We also outline regulation steps that remain unanswered in how the action is communicated across long distances along a DNA contour in DNA mismatch repair.
许多 DNA 代谢途径，包括 DNA 修复，需要在长片段的 DNA 或 DNA 分子之间传递信号。这些信号传递挑战的解决方案涉及各种机制：蛋白质因子可以在这些位点之间移动，将 DNA 环化在这些位点之间，或形成寡聚体来桥接空间间隙。本综述概述了这些范例如何用于解释涉及多个需要远距离作用的步骤的 DNA 错配修复。在这里，我们详细描述了这些模型，以及当前的数据如何符合这些描述。我们还概述了 DNA 错配修复中沿 DNA 轮廓长距离传递作用的调节步骤，这些步骤仍然没有答案。
