TRIB1 rs17321515 和 rs2954029 基因多态性增加中国汉族人群非酒精性脂肪性肝病的风险。
TRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of non-alcoholic fatty liver disease in Chinese Han population.
机构信息
Medical College of Qingdao University, Qingdao, 266071, China.
Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao, 266011, Shandong Province, China.
出版信息
Lipids Health Dis. 2019 Mar 9;18(1):61. doi: 10.1186/s12944-019-1001-z.
BACKGROUND
Dysregulation of the lipid homeostasis is an independent risk factor for non-alcoholic fatty liver disease (NAFLD). Some studies had demonstrated that TRIB1 gene polymorphisms affect the plasma lipids metabolism, but no related data was available for TRIB1 gene polymorphisms in the lipids metabolism in Chinses Han population. The present study was conducted to investigate the association between TRIB1 gene polymorphisms (rs17321515 and rs2954029) and the risk of NAFLD in Chinese Han population and their effects on serum lipid profiles.
PATIENTS AND METHODS
TRIB1 rs17321515 and rs2954029 gene polymorphisms were genotyped using the polymerase chain reaction (PCR) in B-type ultrasonography-proven NAFLD patients (n = 146) and healthy controls (n = 175). Serum lipid profiles were determined using biochemical methods. Statistical analyses were performed using SPSS 22.0 statistical software.
RESULTS
The allele distributions of TRIB1 rs17321515 A and rs2954029 A were significant different between the NAFLD patients and healthy controls (P = 0.026, P = 0.045, respectively). The genotype distribution of TRIB1 rs17321515 was significant different between NAFLD patients and healthy controls (P = 0.038). The TRIB1 rs17321515 GA + AA genotype and TRIB1 rs2954029 TA + AA genotype markedly increase the NAFLD risk (OR = 1.885; 95%CI: 1.157-3.070; OR = 1.627; 95%CI: 1.011-2.619, respectively), after adjusted for age, gender, and body mass index, the NAFLD risk still significant (OR = 2.240; 95%CI: 1.196-4.197; OR = 2.050; 95%CI: 1.110-3.786, respectively). In addition, TRIB1 rs17321515 A and rs2954029 A carriers possess the higher lipid profiles in the included subjects.
CONCLUSIONS
TRIB1 rs17321515 and rs2954029 were significant associated with the risk of NAFLD in Chinese Han population. The rs17321515 A and rs2954029 A allele increases the serum lipid profiles in Chinese Han population.
背景
脂质稳态失调是非酒精性脂肪性肝病（NAFLD）的独立危险因素。一些研究表明 TRIB1 基因多态性影响血浆脂质代谢，但中国汉族人群中TRIB1 基因多态性与脂质代谢的相关数据尚不清楚。本研究旨在探讨 TRIB1 基因多态性（rs17321515 和 rs2954029）与中国汉族人群 NAFLD 风险的关系及其对血清脂质谱的影响。
患者和方法
采用聚合酶链反应（PCR）法对 B 型超声证实的 NAFLD 患者（n=146）和健康对照者（n=175）的 TRIB1 rs17321515 和 rs2954029 基因多态性进行基因分型。采用生化方法测定血清脂质谱。采用 SPSS 22.0 统计软件进行统计学分析。
结果
TRIB1 rs17321515 的 A 等位基因和 rs2954029 的 A 等位基因在 NAFLD 患者和健康对照组之间的分布差异有统计学意义（P=0.026，P=0.045）。TRIB1 rs17321515 的基因型分布在 NAFLD 患者和健康对照组之间有显著差异（P=0.038）。TRIB1 rs17321515 GA+AA 基因型和 rs2954029 TA+AA 基因型显著增加 NAFLD 发病风险（OR=1.885；95%CI：1.157-3.070；OR=1.627；95%CI：1.011-2.619），经年龄、性别和体重指数校正后，NAFLD 发病风险仍显著升高（OR=2.240；95%CI：1.196-4.197；OR=2.050；95%CI：1.110-3.786）。此外，TRIB1 rs17321515 A 和 rs2954029 A 携带者在纳入的研究对象中具有更高的血脂谱。
结论
TRIB1 rs17321515 和 rs2954029 与中国汉族人群的 NAFLD 发病风险显著相关。TRIB1 rs17321515 的 A 等位基因和 rs2954029 的 A 等位基因增加了中国汉族人群的血清脂质谱。
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