Hirose T, Sano T, Hizawa K
First Department of Pathology, University of Tokushima School of Medicine, Japan.
Ultrastruct Pathol. 1988 Jan-Feb;12(1):107-16. doi: 10.3109/01913128809048479.
Six malignant schwannomas were studied by electron microscopy and immunohistochemistry for S-100 protein at the light and electron microscopic levels to clarify the nature of the tumor cells. Three tumors (group A) were composed of poorly differentiated tumor cells and showed no immunoreactivity for S-100 protein. One tumor (group B) was composed of perineurial cells that were S-100 protein-negative. Two tumors (group C) consisted of both Schwann cells and fibroblastic cells like neurofibromas, and only the former were found to contain S-100 protein. Thus, this study showed the heterogeneous nature of the malignant schwannomas and suggested that these tumors might arise from multipotential Schwann cells or different cellular components of peripheral nerve or primitive cells.
通过电子显微镜和免疫组织化学方法，在光镜和电镜水平对6例恶性神经鞘瘤进行S-100蛋白研究，以明确肿瘤细胞的性质。3例肿瘤（A组）由低分化肿瘤细胞组成，对S-100蛋白无免疫反应性。1例肿瘤（B组）由S-100蛋白阴性的神经束膜细胞组成。2例肿瘤（C组）由施万细胞和成纤维细胞样细胞组成，类似神经纤维瘤，仅前者含有S-100蛋白。因此，本研究显示了恶性神经鞘瘤的异质性，并提示这些肿瘤可能起源于多潜能施万细胞、周围神经的不同细胞成分或原始细胞。
