Laboratory of Ornithopathology, Department of Veterinary Pathology, Sao Paulo State University, Jaboticabal, Brazil.
Department of Animal Science, Federal University of Paraiba, Areia, Brazil.
Microb Drug Resist. 2021 Apr;27(4):553-561. doi: 10.1089/mdr.2020.0189. Epub 2020 Aug 18.
Genomic analysis of a methicillin-resistant (MRSA) strain cultured from a non-migratory seabird at Fernando de Noronha Archipelago (Brazilian oceanic islands) was carried out to investigate the potential origin of MRSA genetic determinants in an ecological setting with minimal or absent antimicrobial selective pressure, and minimal interaction with humans and domestic animals. The study determined A gene homology and the phylogenetic relatedness with A described in , which was the major spp. cultured from the birds. Our findings corroborate assumptions that the A gene in MRSA strains clinically relevant for humans and animals originates from ancestors. Coagulase-negative staphylococci seem to be natural reservoirs of methicillin-resistant genes to , even in environments with very low antimicrobial selection pressure.
对从费尔南多-迪诺罗尼亚群岛（巴西海洋岛屿）的一种非迁徙海鸟身上培养出的耐甲氧西林金黄色葡萄球菌（MRSA）菌株进行基因组分析，以研究在生态环境中，最小或不存在抗生素选择压力、最小与人畜相互作用的情况下，MRSA 遗传决定因素的潜在来源。该研究确定了与 中描述的 A 基因同源性和系统发育关系，这是从鸟类中培养出来的主要 spp.。我们的研究结果证实了以下假设，即对人和动物具有临床相关性的 MRSA 菌株中的 A 基因来源于 祖先。凝固酶阴性葡萄球菌似乎是耐甲氧西林基因向 的天然储库，即使在抗生素选择压力非常低的环境中也是如此。
