IEEE Trans Biomed Eng. 2021 Mar;68(3):869-880. doi: 10.1109/TBME.2020.3018266. Epub 2021 Feb 18.
Targeted drug delivery using magnetic particles (MPs) and external magnets for focusing them at the diseased regions, called magnetic drug targeting (MDT), is a next-generation therapeutic method that is being continually improved. However, most existing magnetic systems cannot focus MPs in the targeted region due to there not being enough magnetic capturing force and absence of schemes to generate localized high magnetic field at the wall of the target region. This paper suggests a novel scheme to utilize half of a static saddle potential energy configuration generated using four electromagnets that not only enhances the pushing magnetic forces but also simultaneously generates pushing and attracting forces in the desired direction to help focus spherical MPs on the wall of the target region. Furthermore, by changing amplitudes or directions of the currents, the focal point in the target region can be changed. Through extensive simulations and in vitro experiments, we demonstrate that half of a static saddle magnetic potential energy configuration can be successfully utilized to attract and focus MPs at the wall of a target region.
利用磁性颗粒（MPs）和外部磁铁将其聚焦在病变区域的靶向药物输送（MDT）是一种正在不断改进的下一代治疗方法。然而，由于缺乏足够的磁捕获力以及在目标区域壁上产生局部强磁场的方案，大多数现有的磁性系统无法将 MPs 聚焦在靶向区域。本文提出了一种新颖的方案，利用四个电磁体产生的半静态鞍形势能配置，不仅增强了推动磁力，还同时在所需方向上产生推动和吸引磁力，以帮助将球形 MPs 聚焦在目标区域的壁上。此外，通过改变电流的幅度或方向，可以改变目标区域中的焦点。通过广泛的模拟和体外实验，我们证明可以成功利用半静态鞍形磁势能配置来吸引和聚焦目标区域壁上的 MPs。
