Simpson P, Forsling M
Clin Endocrinol (Oxf). 1977 Jul;7(1):33-9. doi: 10.1111/j.1365-2265.1977.tb02937.x.
Plasma vasopressin concentrations were estimated in twelve patients undergoing cardio-pulmonary bypass for open heart surgery. In six patients anaesthesia was maintained with 66% nitrous oxide in oxygen, whilst the remaining six additionally received halothan as a vasodilator during the bypass period. Induction of anaesthesia had little effect on plasma vasopressin concentrations, whilst marked increases were seen during surgery and bypass in both groups of patients. However, in those patients receiving halothane, significantly higher concentrations were reached, a maximun b36.1 +/- 8.9 (SEM) muu/ml being seen in contrase to 15.4 +/- 2.2 muu/ml in the group receiving nitrous oxide in oxygen alone.
对12例接受心脏直视手术体外循环的患者测定了血浆血管加压素浓度。6例患者在麻醉期间吸入66%氧化亚氮和氧气维持麻醉，其余6例在体外循环期间还加用氟烷作为血管扩张剂。麻醉诱导对血浆血管加压素浓度影响不大，但两组患者在手术和体外循环期间均出现显著升高。然而，接受氟烷的患者血浆血管加压素浓度明显更高，最高达36.1±8.9（标准误）mU/ml，而仅吸入氧化亚氮和氧气的组为15.4±2.2 mU/ml。
