Japan Chemical Analysis Center, Sanno 295-3, Inage, Chiba, 263-0002, Japan.
Japan Chemical Analysis Center, Sanno 295-3, Inage, Chiba, 263-0002, Japan.
Appl Radiat Isot. 2020 Oct;164:109106. doi: 10.1016/j.apradiso.2020.109106. Epub 2020 Jun 10.
Boron Neutron Capture Therapy (BNCT) is a radiotherapy for the treatment of intractable cancer. In BNCT precise determination of B concentration in whole blood sample before neutron irradiation of the patient, as well as accurate neutron dosimetry, is crucial for control of the neutron irradiation time. For this purpose ICP-AES and neutron induced prompt γ-ray analysis are generally used. In Ibaraki Neutron Medical Research Center (iNMRC), an intense proton beam will be accelerated up to 8 MeV, which can also be used for Charged Particle Activation Analysis (CPAA). Thus, in this study, we apply the CPAA utilizing the proton beam to non-destructive and accurate determination of B concentration in whole blood sample. A CPAA experiment is performed by utilizing an 8 MeV proton beam from the tandem accelerator of Nuclear Science Research Institute in Japan Atomic Energy Agency. The 478 keV γ-ray of Be produced by the B(p, α)Be reaction is used to quantify the B in human blood. The 478 keV γ-ray intensity is normalized by the intensities of the 847 keV and 1238 keV γ-rays of Co originating from Fe in blood. The normalization methods were found to be linear in the range of 3.27 μg B/g to 322 μg B/g with correlation coefficients of better than 0.9999.
硼中子俘获治疗（BNCT）是一种用于治疗难治性癌症的放射疗法。在 BNCT 中，在给患者进行中子辐照之前，精确测定全血样本中的硼浓度，以及准确的中子剂量测定，对于控制中子辐照时间至关重要。为此，通常使用电感耦合等离子体原子发射光谱法（ICP-AES）和中子诱发瞬发伽马射线分析。在茨城县中子医疗研究中心（iNMRC），将加速强度高达 8 MeV 的质子束，也可用于带电粒子活化分析（CPAA）。因此，在这项研究中，我们应用 CPAA 利用质子束对全血样本中的硼浓度进行非破坏性和精确测定。通过利用日本原子能机构核科学研究所的串列加速器中的 8 MeV 质子束进行 CPAA 实验。利用 B(p,α)Be 反应产生的 Be 的 478 keV 伽马射线来定量测定人血液中的硼。通过将源自血液中铁的 847 keV 和 1238 keV γ 射线的强度归一化，来标准化 478 keV γ 射线强度。在 3.27 μg B/g 至 322 μg B/g 的范围内，发现归一化方法呈线性关系，相关系数均优于 0.9999。
