用于快速生物传感的对流驱动微加工水凝胶。
Convection-driven microfabricated hydrogels for rapid biosensing.
作者信息
Cheng Cheng, Harpster Mark H, Oakey John
机构信息
Department of Chemical Engineering, University of Wyoming, Laramie, WY 82070, USA.
出版信息
Analyst. 2020 Sep 14;145(18):5981-5988. doi: 10.1039/d0an01069c.
Abstract
A microscale biosensing platform using rehydration-mediated swelling of bio-functionalized hydrogel structures and rapid target analyte capture is described. Induced convective flow mitigates diffusion limited incubation times, enabling model assays to be completed in under three minutes. Assay design parameters have been evaluated, revealing fabrication criteria required to tune detection sensitivity.
摘要
描述了一种使用生物功能化水凝胶结构的再水化介导肿胀和快速捕获目标分析物的微尺度生物传感平台。诱导对流流动减轻了扩散限制的孵育时间，使模型分析能够在三分钟内完成。已经评估了分析设计参数，揭示了调整检测灵敏度所需的制造标准。
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