Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
J Am Chem Soc. 2020 Sep 9;142(36):15271-15275. doi: 10.1021/jacs.0c08187. Epub 2020 Aug 26.
Small molecular fluorophores in the second near-infrared window (NIR-II) have aroused much interest because of their excellent performance. Herein, a new small molecular NIR-II fluorophore, FM1210, with maximal emission beyond 1200 nm is reported. Compared to the corresponding control fluorophore CF1065, FM1210 exhibits an increase of 145 nm in the emission maximum, which is ascribed to the simultaneous introduction of both a Se atom and amino groups into the benzo[1,2-:4,5-']bis([1,2,5]thiadiazole) skeleton. This large increase in the maximal emission enables FM1210 to be capable of imaging with lower autofluorescence, higher signal-to-background ratio, and better resolution. Moreover, nanosized FM1210 encapsulated in liposomes possesses passive targeting ability and good water solubility, and is suitable for imaging a tumor and even its vasculature with high signal-to-background ratio.
小分子近红外二区（NIR-II）荧光团因其优异的性能而引起了广泛关注。在此，报道了一种新的小分子 NIR-II 荧光团 FM1210，其最大发射波长超过 1200nm。与相应的对照荧光团 CF1065 相比，FM1210 的最大发射波长增加了 145nm，这归因于同时将一个 Se 原子和氨基引入苯并[1,2-:4,5-']双([1,2,5]噻二唑)骨架中。这种最大发射的大幅增加使得 FM1210 能够进行低自发荧光、高信噪比和更好分辨率的成像。此外，包封在脂质体中的纳米级 FM1210 具有被动靶向能力和良好的水溶性，适用于高信噪比的肿瘤及其血管成像。
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