Albanese R, Mirkova E, Gatehouse D, Ashby J
ICI Pharmaceuticals Division, Macclesfield, Cheshire, UK.
Mutagenesis. 1988 Jan;3(1):35-8. doi: 10.1093/mutage/3.1.35.
1,2-Dimethylhydrazine is confirmed as active in the mouse bone-marrow micronucleus assay when administered as an aqueous solution via oral gavage to three different strains of mice. It is also shown to be inactive in a corresponding rat assay under similar conditions of test. The observations were independently repeated in two laboratories. In contrast, 1,2-dibromo-3-chloropropane showed the reverse profile, being active in the rat bone-marrow assay but inactive in the mouse; the latter observations were also made in two laboratories. The carcinogen procarbazine was active in both species. These findings are discussed within the context of the present GeneTox revision of the standard test protocol of the rodent bone-marrow micronucleus assay.
当通过口服灌胃以水溶液形式给予三种不同品系的小鼠时，1,2 - 二甲基肼在小鼠骨髓微核试验中被确认为具有活性。在相似的试验条件下，它在相应的大鼠试验中也显示无活性。这些观察结果在两个实验室中独立重复进行。相比之下，1,2 - 二溴 - 3 - 氯丙烷表现出相反的情况，在大鼠骨髓试验中具有活性，但在小鼠中无活性；后者的观察结果同样是在两个实验室中得出的。致癌物丙卡巴肼在两种动物中均具有活性。在当前啮齿动物骨髓微核试验标准测试方案的基因毒性修订版背景下对这些发现进行了讨论。
