Schaub N, Stalder H, Stalder G A, Marbet U A, Vögtlin J, Affolter H, Wegmann W, Vischer W A, Zingel O, Tanner K
Medizinische Klinik, Kantonsspital Liestal.
Schweiz Med Wochenschr. 1988 Mar 5;118(9):293-301.
In a prospective study of 70 patients with epigastric pain, gastroduodenoscopy revealed gastric and/or duodenal ulcers in a total of 41 and no ulceration in the remainder. Biopsies were taken to assess the severity of gastritis and the presence of Campylobacter pylori (CP) by histology and culture. Gastritis was found in 54 patients. CP was detected in 78% of the ulcer patients and 52% of the patients without ulcer (p less than 0.05). CP was demonstrated in 83% of the histologically diagnosed cases of gastritis (all grades) but no CP was detectable in patients with normal gastric mucosa. Among the ulcer patients, CP was more frequent in those with no history of medication with nonsteroidal antiinflammatory drugs (p less than 0.01). Sera from CP-positive ulcer and gastritis patients have significantly higher levels of IgG antibodies to CP than sera from those found to be free of ulcer or gastritis. In 200 blood donors an increasing percentage of elevated CP-antibody titres were found with advancing age (50% over 60 years of age). Quantification of circulating CP antibodies, would thus seem a valuable adjunct in the diagnosis of gastritis and probably also of peptic ulcer. The data presented furnish further evidence of the high rate of association of CP and the gastritis-peptic ulcer complex.
在一项对70例上腹部疼痛患者的前瞻性研究中，胃肠镜检查发现41例患者有胃和/或十二指肠溃疡，其余患者未发现溃疡。取活检组织通过组织学和培养评估胃炎的严重程度以及幽门弯曲菌（CP）的存在情况。54例患者发现有胃炎。在溃疡患者中，78%检测到CP，无溃疡患者中52%检测到CP（p<0.05）。在组织学诊断为胃炎（所有分级）的病例中，83%检测到CP，但胃黏膜正常的患者未检测到CP。在溃疡患者中，无非甾体抗炎药用药史的患者CP感染更为常见（p<0.01）。CP阳性的溃疡和胃炎患者血清中抗CP的IgG抗体水平明显高于未患溃疡或胃炎患者的血清。在200名献血者中，随着年龄增长，CP抗体滴度升高的百分比增加（60岁以上者为50%）。因此，循环CP抗体的定量检测似乎是诊断胃炎以及可能的消化性溃疡的一项有价值的辅助手段。所提供的数据进一步证明了CP与胃炎 - 消化性溃疡复合体的高关联率。
