Johnson G S, Turrentine M A, Kraus K H
Department of Veterinary Pathology, University of Missouri College of Veterinary Medicine, Columbia.
Vet Clin North Am Small Anim Pract. 1988 Jan;18(1):195-229. doi: 10.1016/s0195-5616(88)50017-7.
The term "von Willebrand's disease," refers to a group of inherited bleeding disorders, all of which are caused by a deficiency of the multimeric plasma glycoprotein, von Willebrand factor. The various forms of canine von Willebrand's disease can be categorized into one of three major types: in type I canine von Willebrand's disease, all sizes of von Willebrand factor multimers can be detected in the plasma; in type II canine von Willebrand's disease, only the smaller von Willebrand factor multimers are found in the plasma (larger multimers are absent); and in type III canine von Willebrand's disease, von Willebrand factor is completely absent from the plasma or present in only trace amounts. Von Willebrand's disease is common in dogs, but some forms of the disease are so mild that they are of questionable clinical significance.
术语“血管性血友病”指的是一组遗传性出血性疾病，所有这些疾病都是由多聚体血浆糖蛋白血管性血友病因子缺乏引起的。犬血管性血友病的各种形式可分为三大主要类型之一：在I型犬血管性血友病中，血浆中可检测到各种大小的血管性血友病因子多聚体；在II型犬血管性血友病中，血浆中仅发现较小的血管性血友病因子多聚体（不存在较大的多聚体）；在III型犬血管性血友病中，血浆中完全不存在血管性血友病因子或仅存在微量。血管性血友病在犬类中很常见，但某些形式的疾病非常轻微，其临床意义存疑。
