Department of Nursing, School of Medicine, Chosun University, Gwangju 61452, Korea.
Department of Preventive Medicine, School of Medicine, Chosun University, Gwangju 61452, Korea.
Int J Environ Res Public Health. 2018 Aug 5;15(8):1658. doi: 10.3390/ijerph15081658.
The purpose of this study was to evaluate the association between alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and metabolic syndrome (MS) in the Korean population. A total of 11,587 adults ≥30 years of age and with complete data were selected from Korea National Health and Nutrition Examination Survey VI conducted from 2013 to 2015. Normal ALT and AST levels were divided into quartiles, and their associations with MS were assessed by logistic regression analysis. Elevated levels of ALT [adjusted odds ratio (aOR) = 7.90, 95% confidence interval (CI) = 6.50⁻9.60] and AST (aOR = 3.81, 95% CI = 3.10⁻4.74) were both significantly associated with a higher prevalence of MS. The quartile group containing the highest levels of ALT and AST within the normal range also showed an increased risk of MS and its components. Elevated levels of ALT and AST, even within the normal range, were associated with prevalence of MS.
本研究旨在评估丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）与韩国人群代谢综合征（MS）之间的关系。从 2013 年至 2015 年进行的韩国国家健康和营养检查调查 VI 中，选择了 11587 名年龄≥30 岁且具有完整数据的成年人。将正常 ALT 和 AST 水平分为四等份，并通过 logistic 回归分析评估其与 MS 的关系。升高的 ALT 水平[调整后的优势比（aOR）=7.90，95%置信区间（CI）=6.50⁻9.60]和 AST（aOR=3.81，95%CI=3.10⁻4.74）均与 MS 的高患病率显著相关。在正常范围内 ALT 和 AST 水平最高的四分位组也显示出 MS 及其成分的风险增加。即使在正常范围内，升高的 ALT 和 AST 水平也与 MS 的患病率相关。
