Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland.
Department of Pneumology, Kantonsspital St. Gallen, Rorschacherstrasse 95, St. Gallen, CH-9001, Switzerland.
Respir Res. 2020 Aug 21;21(1):220. doi: 10.1186/s12931-020-01473-2.
Reflux of gastric content has been associated with recurrent exacerbations of chronic obstructive pulmonary disease (COPD). We aimed to assess the prevalence of laryngopharyngeal reflux (LPR) in COPD and if LPR is a contributing factor to clinically relevant outcomes in COPD. We evaluated a total of 193 COPD patients (GOLD I-IV) with a 24-h laryngo-pharyngeal pΗ-monitor. LPR was observed in 65.8% of COPD patients and it was not significantly associated with clinically relevant outcomes of COPD. Treatment with PPI significantly decreased the upright RYAN score (p = 0.047) without improving lung function. Furthermore, the presence or severity of LPR cannot be diagnosed based solely on symptoms and questionnaires.
胃内容物反流与慢性阻塞性肺疾病（COPD）的反复发作有关。我们旨在评估 LPR（喉咽反流）在 COPD 中的患病率，以及 LPR 是否是 COPD 中临床相关结局的一个促成因素。我们评估了总共 193 名 COPD 患者（GOLD I-IV）的 24 小时喉咽 pH 监测。在 65.8%的 COPD 患者中观察到 LPR，但它与 COPD 的临床相关结局无显著相关性。PPI 治疗显著降低了直立 RYAN 评分（p=0.047），而对肺功能没有改善。此外，不能仅根据症状和问卷来诊断 LPR 的存在或严重程度。
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