Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
World J Gastroenterol. 2024 Apr 28;30(16):2209-2219. doi: 10.3748/wjg.v30.i16.2209.
Laryngopharyngeal reflux disease (LPRD) is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the esophagus. LPRD commonly presents with sym-ptoms such as hoarseness, cough, sore throat, a feeling of throat obstruction, excessive throat mucus. This complex condition is thought to involve both reflux and reflex mechanisms, but a clear understanding of its molecular mechanisms is still lacking. Currently, there is no standardized diagnosis or treatment protocol. Therapeutic strategies for LPRD mainly include lifestyle modifications, proton pump inhibitors and endoscopic surgery. This paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms, patho-physiology and treatment of LPRD. We also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.
喉咽反流病（LPRD）是一种喉咽和上呼吸道黏膜的炎症性疾病，由胃内容物反流超过食管引起。LPRD 常表现为声音嘶哑、咳嗽、喉咙痛、喉咙阻塞感、喉咙黏液过多等症状。这种复杂的情况被认为涉及反流和反射机制，但对其分子机制的认识仍不清楚。目前，尚无标准化的诊断或治疗方案。LPRD 的治疗策略主要包括生活方式改变、质子泵抑制剂和内镜手术。本文旨在对 LPRD 的发病机制、病理生理学和治疗的现有文献进行全面综述。我们还深入探讨了 LPRD 与胃食管反流病之间的关联。
