Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; Human Technopole, Milan, Italy.
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Trends Neurosci. 2020 Nov;43(11):843-853. doi: 10.1016/j.tins.2020.07.009. Epub 2020 Aug 20.
The evolutionary expansion of the mammalian neocortex is widely considered to be a basis of increased cognitive abilities. This expansion is a consequence of the enhanced production of neurons during the fetal/embryonic development of the neocortex, which in turn reflects an increased proliferative capacity of neural progenitor cells; in particular basal progenitors (BPs). The remarkable heterogeneity of BP subtypes across mammals, notably their various morphotypes and molecular fingerprints, which has recently been revealed, corroborates the importance of BPs for neocortical expansion. Here, we argue that the morphology of BPs is a key cell biological basis for maintaining their high proliferative capacity and therefore plays crucial roles in the evolutionary expansion of the neocortex.
哺乳动物新皮层的进化扩张被广泛认为是认知能力提高的基础。这种扩张是新皮层胎儿/胚胎发育过程中神经元产量增加的结果，而这又反映了神经祖细胞（尤其是基底祖细胞，BPs）增殖能力的增强。最近揭示的哺乳动物 BP 亚型的显著异质性，特别是它们不同的形态和分子指纹，证实了 BPs 对新皮层扩张的重要性。在这里，我们认为 BP 的形态是维持其高增殖能力的关键细胞生物学基础，因此在新皮层的进化扩张中发挥着关键作用。
