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First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data.首发精神病患者在病前阶段恶化者的多基因风险评分并不高于其他人：EU-GEI 数据的聚类分析。
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本文引用的文献

1
Polygenic risk scores: from research tools to clinical instruments.多基因风险评分：从研究工具到临床工具。
Genome Med. 2020 May 18;12(1):44. doi: 10.1186/s13073-020-00742-5.
2
Schizophrenia polygenic risk score and 20-year course of illness in psychotic disorders.精神分裂症多基因风险评分与精神病性障碍 20 年病程。
Transl Psychiatry. 2019 Nov 14;9(1):300. doi: 10.1038/s41398-019-0612-5.
3
Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits.遗传易感性与神经精神障碍和特征性精神体验的关联。
JAMA Psychiatry. 2019 Dec 1;76(12):1256-1265. doi: 10.1001/jamapsychiatry.2019.2508.
4
Association Between Population Density and Genetic Risk for Schizophrenia.人口密度与精神分裂症遗传风险之间的关联。
JAMA Psychiatry. 2018 Sep 1;75(9):901-910. doi: 10.1001/jamapsychiatry.2018.1581.
5
A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.一项针对大脑功能、结构和认知领域的精神病内表型的多基因风险评分分析。
Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):21-34. doi: 10.1002/ajmg.b.32581. Epub 2017 Aug 29.
6
An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis.对首发精神病患者多基因风险评分预测的研究
Biol Psychiatry. 2017 Mar 15;81(6):470-477. doi: 10.1016/j.biopsych.2016.06.028. Epub 2016 Aug 6.
7
Urban-rural differences in incidence rates of psychiatric disorders in Denmark.丹麦精神障碍发病率的城乡差异。
Br J Psychiatry. 2016 May;208(5):435-40. doi: 10.1192/bjp.bp.114.161091. Epub 2015 Dec 17.
8
Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.精神分裂症和双相情感障碍的多基因风险评分可预测创造力。
Nat Neurosci. 2015 Jul;18(7):953-5. doi: 10.1038/nn.4040. Epub 2015 Jun 8.
9
Biological insights from 108 schizophrenia-associated genetic loci.108 个精神分裂症相关遗传位点的生物学见解。
Nature. 2014 Jul 24;511(7510):421-7. doi: 10.1038/nature13595. Epub 2014 Jul 22.
10
Heritability in the genomics era--concepts and misconceptions.基因组学时代的遗传力——概念与误解
Nat Rev Genet. 2008 Apr;9(4):255-66. doi: 10.1038/nrg2322. Epub 2008 Mar 4.

Nature, Nurture, and the Polygenic Risk Score for Schizophrenia.

作者信息

Murray Robin M, Vassos Evangelos

机构信息

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

出版信息

Schizophr Bull. 2020 Dec 1;46(6):1363-1365. doi: 10.1093/schbul/sbaa119.

DOI:10.1093/schbul/sbaa119
PMID:32829401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7707072/
Abstract
摘要