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Bothrofav®抗蛇毒血清对毒液临床前疗效的第三代抗蛇毒血清组学分析。

Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards venom.

作者信息

Pla Davinia, Rodríguez Yania, Resiere Dabor, Mehdaoui Hossein, Gutiérrez José María, Calvete Juan J

机构信息

Laboratorio de Venómica Evolutiva y Traslacional, Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010 Valencia, Spain.

Service des Urgences et de Reanimation Polyvalente, Centre Hospitalier Universitaire, Fort-de-France, Martinique, France.

出版信息

Toxicon X. 2018 Dec 29;1:100004. doi: 10.1016/j.toxcx.2018.100004. eCollection 2019 Jan.

DOI:10.1016/j.toxcx.2018.100004
PMID:32831345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7286001/
Abstract

inflicts severe envenomings in the Lesser Caribbean island of Martinique. Bothrofav®, a monospecific antivenom against venom, has proven highly effective at the preclinical and clinical levels. Here, we report a detailed third-generation antivenomics quantitative analysis of Bothrofav®. With the exception of poorly-immunogenic peptides, Bothrofav® immunocaptured all the major protein components. These results, along with previous preclinical and clinical observations, underscore the high neutralizing efficacy of the antivenom against venom.

摘要

在小安的列斯群岛的马提尼克岛造成严重的蛇毒中毒。Bothrofav®是一种针对[蛇名未给出]毒液的单特异性抗蛇毒血清，已在临床前和临床水平上证明非常有效。在此，我们报告了对Bothrofav®的详细第三代抗蛇毒血清组学定量分析。除了免疫原性较差的肽段外，Bothrofav®免疫捕获了所有主要蛋白质成分。这些结果，连同先前的临床前和临床观察结果，强调了该抗蛇毒血清对[蛇名未给出]毒液的高中和效力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab04/7286001/a9c9d31693f9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab04/7286001/28ac4e77dafd/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab04/7286001/a9c9d31693f9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab04/7286001/28ac4e77dafd/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab04/7286001/a9c9d31693f9/gr1.jpg

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