Assiri Khalil, Hameed Mohammad Shahul, Dawasaz Ali Azhar, Alamoudi Eman, Asiri Alhussain Mohammad, Hitesh Vij, Ajmal Muhammed
Department of Diagnostic Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.
Department of Rheumatology, Asir Central Hospital, Abha, Kingdom of Saudi Arabia.
Indian J Dermatol. 2020 Jul-Aug;65(4):265-268. doi: 10.4103/ijd.IJD_620_18.
A disease activity score obtained by using systemic lupus erythematosus disease activity index (SLEDAI) has traditionally been a reliable method to assess the SLE status of patients. More recently, a buccal micronucleus cytome assay (BMCA) has been developed for use as a biomarker of DNA damage in patients with SLE. There has been a very limited number of studies pertaining to the oral lesions in Arab population suffering from SLE in Asir region. Hence, it became utmost important to study epidemiological data of oral mucosal lesions in SLE patients. Distribution of oral lesions in SLE patients could also be helpful in better management of oral complications.
The aim of this study was to determine the existence of a correlation between SLEDAI score and the degree of micronuclei (MN) formation using BMCA.
After thorough oral examination of adult Saudi SLE patients of Asir hospital and that of healthy control subjects, the subjects underwent BMCA from normal unaffected bilateral buccal mucosae.
Pearson's correlation test showed that MN count did not significantly correlate with either disease activity or duration of SLE.
Controlled state SLE does not lead to a significant increase in MN formation. Thus, the occurrence of premalignant lesions in the oral cavity could be minimized using proper management protocols.
传统上，使用系统性红斑狼疮疾病活动指数（SLEDAI）获得的疾病活动评分一直是评估患者SLE状态的可靠方法。最近，一种颊黏膜微核细胞分析法（BMCA）已被开发用作SLE患者DNA损伤的生物标志物。在阿西尔地区患有SLE的阿拉伯人群中，有关口腔病变的研究数量非常有限。因此，研究SLE患者口腔黏膜病变的流行病学数据变得至关重要。SLE患者口腔病变的分布也有助于更好地管理口腔并发症。
本研究的目的是确定使用BMCA时SLEDAI评分与微核（MN）形成程度之间是否存在相关性。
在对阿西尔医院的成年沙特SLE患者和健康对照者进行全面口腔检查后，受试者从正常未受影响的双侧颊黏膜进行BMCA。
Pearson相关性检验显示，MN计数与SLE的疾病活动或病程均无显著相关性。
SLE的可控状态不会导致MN形成显著增加。因此，使用适当的管理方案可以将口腔癌前病变的发生降至最低。
