Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Department of Laboratory Medicine, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, China.
Mediators Inflamm. 2020 Aug 4;2020:7903140. doi: 10.1155/2020/7903140. eCollection 2020.
Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity (MHO) phenotype) and the association of NPY with MUO phenotype have not been unequivocally established. We therefore determined associations of serum NPY levels with MUO phenotype in obese Chinese adults.
A cross-sectional study was conducted from 400 obese adults in Hunan province, who underwent a health examination in the Second Xiangya Hospital, and 164 participants were finally enrolled in the study and divided into MHO and MUO groups. Serum NPY levels were examined; univariate and multivariate analyses as well as smooth curve fitting analyses were conducted to measure the association of NPY serum levels with the MUO phenotype.
Serum NPY levels were significantly elevated in the MUO group compared with the MHO group ((667.69 ± 292.90) pg/mL vs. (478.89 ± 145.53) pg/mL, < 0.001). A threshold and nonlinear association between serum NPY levels and MUO was found ( = 0.001). When serum NPY levels exceeded the turning point (471.5 pg/mL), each 10 pg/mL increment in the NPY serum level was significantly associated with an 18% increased odds ratio of MUO phenotype (OR: 1.18, 95% CI: 1.07-1.29, = 0.0007) after adjusted for confounders.
Higher NPY serum levels were positively correlated with MUO phenotype in obese Chinese adults.
神经肽 Y（NPY）是一种已知能引起多食的食欲肽，它与肥胖的发生和发展有关。然而，肥胖表型（包括代谢不健康的肥胖（MUO）表型和代谢健康的肥胖（MHO）表型）中血清 NPY 水平的分布差异以及 NPY 与 MUO 表型的关系尚未明确。因此，我们确定了血清 NPY 水平与中国肥胖成年人 MUO 表型的相关性。
对湖南省 400 名肥胖成年人进行横断面研究，他们在湘雅二医院进行了健康检查，最终有 164 名参与者被纳入研究，并分为 MHO 和 MUO 组。检测血清 NPY 水平；进行单变量和多变量分析以及平滑曲线拟合分析，以测量 NPY 血清水平与 MUO 表型的相关性。
MUO 组血清 NPY 水平明显高于 MHO 组（（667.69 ± 292.90）pg/mL 比（478.89 ± 145.53）pg/mL，<0.001）。血清 NPY 水平与 MUO 之间存在阈值和非线性关系（=0.001）。当血清 NPY 水平超过转折点（471.5 pg/mL）时，NPY 血清水平每增加 10 pg/mL，MUO 表型的优势比（OR）显著增加 18%（OR：1.18，95%CI：1.07-1.29，=0.0007），校正混杂因素后。
在肥胖的中国成年人中，较高的 NPY 血清水平与 MUO 表型呈正相关。
