Gonzalez David J X, Sherris Allison R, Yang Wei, Stevenson David K, Padula Amy M, Baiocchi Michael, Burke Marshall, Cullen Mark R, Shaw Gary M
Emmett Interdisciplinary Program in Environment and Resources, Stanford University, Stanford, California.
Department of Pediatrics, School of Medicine, Stanford University, Stanford, California.
Environ Epidemiol. 2020 Jun 5;4(4):e099. doi: 10.1097/EE9.0000000000000099. eCollection 2020 Aug.
Recent studies report an association between preterm birth and exposure to unconventional oil and gas wells. There has been limited previous study on exposure to conventional wells, which are common in California. Our objective was to determine whether exposure to well sites was associated with increased odds of spontaneous preterm birth (delivery at <37 weeks).
We conducted a case-control study using data on 27,913 preterm birth cases and 197,461 term birth controls. All births were without maternal comorbidities and were located in the San Joaquin Valley, CA, between 1998 and 2011. We obtained data for 83,559 wells in preproduction or production during the study period. We assessed exposure using inverse distance-squared weighting and, for each birth and trimester, we assigned an exposure tertile. Using logistic regression, we estimated adjusted odds ratios (ORs) for the association between exposure to well sites and preterm birth at 20-27, 28-31, and 32-36 weeks.
We observed increased ORs for preterm birth with high exposure to wells in the first and second trimesters for births delivered at ≤31 weeks (adjusted ORs, 1.08-1.14). In stratified analyses, the associations were confined to births to Hispanic and non-Hispanic Black women and to women with ≤12 years of educational attainment. In a secondary analysis, we found evidence that exposure to wells in preproduction is associated with higher concentrations of particulate matter.
We found evidence that exposure to oil and gas well sites is associated with increased risk of spontaneous preterm birth.
近期研究报告了早产与接触非常规油气井之间的关联。此前关于接触常规油井的研究有限，而常规油井在加利福尼亚州很常见。我们的目标是确定接触油井场地是否与自然早产（孕37周前分娩）几率增加有关。
我们进行了一项病例对照研究，使用了27913例早产病例和197461例足月产对照的数据。所有分娩的产妇均无合并症，且于1998年至2011年期间位于加利福尼亚州圣华金谷。我们获取了研究期间处于预生产或生产阶段的83559口油井的数据。我们使用反距离平方加权法评估接触情况，并为每次分娩和孕期分配一个接触三分位数。使用逻辑回归，我们估计了在20 - 27周、28 - 31周和32 - 36周时接触油井场地与早产之间关联的调整优势比（OR）。
我们观察到，对于孕周≤31周的分娩，在孕早期和孕中期高接触油井的早产OR增加（调整后的OR为1.08 - 1.14）。在分层分析中，这种关联仅限于西班牙裔和非西班牙裔黑人女性以及教育程度≤12年的女性分娩。在一项次要分析中，我们发现有证据表明接触预生产油井与更高浓度的颗粒物有关。
我们发现有证据表明接触油气井场地与自然早产风险增加有关。
