Hu Guang-Qi, Li En-Ci, Zhang Hong-Hai, Huang Wei
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing Tech. University (Nanjing Tech.), 30 Puzhu Road, Nanjing 211816, P. R. China.
Org Biomol Chem. 2020 Sep 14;18(34):6627-6633. doi: 10.1039/d0ob01273d. Epub 2020 Aug 24.
An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by a AgCO/Sphos-mediated HIE protocol with DO as the deuterium source has been disclosed. This method showed a specific site selectivity of deuteration at the α-position of the fluorine atom, which is complementary to the existing transition metal-catalyzed HIE process.
已公开一种通过AgCO/Sphos介导的HIE协议，以DO作为氘源，将氘引入单氟（杂）芳烃的有效方法。该方法在氟原子的α位显示出特定的氘化位点选择性，这与现有的过渡金属催化的HIE过程互补。
