Suppr超能文献

为减轻新冠疫情影响而实施的卡介苗接种策略:炒作还是希望?

BCG vaccination strategy implemented to reduce the impact of COVID-19: Hype or Hope?

作者信息

Rajarshi Keshav, Chatterjee Aroni, Ray Shashikant

机构信息

School of Community Science and Technology (SOCSAT) Indian Institute of Engineering Scince and Technology (IIEST), Shibpur, Howrah, West Bengal 711103, India.

Indian Council of Medical Research (ICMR)-Virus Research Laboratory, NICED, Kolkata, India.

出版信息

Med Drug Discov. 2020 Sep;7:100049. doi: 10.1016/j.medidd.2020.100049. Epub 2020 May 26.

Abstract

The Bacillus Calmette-Guerin vaccine (BCG vaccine) designed to prevent tuberculosis in children has been shown to induce a adaptive immune response in the body to fight against bacteria as well as other parasites and viruses. This knowledge has been reciprocated to generate the idea that this vaccine can also offer protection against severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Some recent pre-print articles have highlighted that countries with mass BCG immunizations seems to have a lower incidence of coronavirus disease 2019 (COVID-19) compared to those without BCG immunization. There are yet no experimental proof of any such association and the world health organisation (WHO) is currently testing the theory with clinical trials on selected cohorts. Epidemiologists and other scientific experts has expressed both their hope and concern simultaneously regarding the success theory of BCG vaccination to prevent COVID-19. Though its still not verified in any way whether the BCG vaccination can actually prevent COVID-19 or not but we believe a thorough analytical research in this regard is indeed worth a shot.

摘要

旨在预防儿童结核病的卡介苗(BCG疫苗)已被证明能在体内诱导适应性免疫反应,以对抗细菌以及其他寄生虫和病毒。基于这一认知,人们由此产生了一种想法,即这种疫苗也可以提供针对严重急性呼吸综合征冠状病毒2(SARS-COV-2)的保护。最近的一些预印本文章强调,与未进行卡介苗大规模接种的国家相比,进行卡介苗大规模接种的国家2019冠状病毒病(COVID-19)的发病率似乎较低。目前尚无任何此类关联的实验证据,世界卫生组织(WHO)正在通过对选定队列进行临床试验来验证这一理论。流行病学家和其他科学专家对卡介苗接种预防COVID-19这一理论的成功既表达了希望,也表达了担忧。尽管目前仍未以任何方式证实卡介苗接种是否真的能预防COVID-19,但我们认为在这方面进行深入的分析研究确实值得一试。

相似文献

6
Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infection.卡介苗(BCG)接种对 COVID-19 感染的影响。
Comput Biol Med. 2021 Nov;138:104891. doi: 10.1016/j.compbiomed.2021.104891. Epub 2021 Sep 29.

引用本文的文献

4
Principles and Challenges in anti-COVID-19 Vaccine Development.抗 COVID-19 疫苗研发的原则与挑战。
Int Arch Allergy Immunol. 2021;182(4):339-349. doi: 10.1159/000514225. Epub 2021 Feb 1.
6
Nucleic acid-based therapy for coronavirus disease 2019.2019冠状病毒病的核酸疗法
Heliyon. 2020 Sep;6(9):e05007. doi: 10.1016/j.heliyon.2020.e05007. Epub 2020 Sep 19.

本文引用的文献

1
Considering BCG vaccination to reduce the impact of COVID-19.考虑接种卡介苗以减轻新型冠状病毒肺炎的影响。
Lancet. 2020 May 16;395(10236):1545-1546. doi: 10.1016/S0140-6736(20)31025-4. Epub 2020 Apr 30.
2
Coronavirus disease 2019 (COVID-19): a clinical update.新型冠状病毒病 2019(COVID-19):临床更新。
Front Med. 2020 Apr;14(2):126-135. doi: 10.1007/s11684-020-0767-8. Epub 2020 Apr 2.
3
The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines.新型冠状病毒肺炎的爆发需要病毒疫苗。
NPJ Vaccines. 2020 Mar 6;5(1):18. doi: 10.1038/s41541-020-0170-0. eCollection 2020.
5
Non-specific effects of BCG vaccine on viral infections.卡介苗疫苗对病毒感染的非特异性作用。
Clin Microbiol Infect. 2019 Dec;25(12):1473-1478. doi: 10.1016/j.cmi.2019.04.020. Epub 2019 May 2.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验