Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Int J Infect Dis. 2020 Nov;100:298-301. doi: 10.1016/j.ijid.2020.08.048. Epub 2020 Aug 21.
To determine the diagnostic yield of repeat testing for SARS-CoV-2.
A retrospective analysis was performed of all SARS-CoV-2 test results within the UCLA Health System between March 9th and April 29th, 2020. All patients with repeat test results were identified and those with discordant results were reviewed.
Between March 9th and April 29th there were 10,165 SARS-CoV-2 test results, of which 630 (6.2%) were positive. Among the 904 patients with repeat test results, 808 (89.4%) were initially negative and 96 (10.6%) were initially positive. Among the 808 patients with an initial negative test, 15 (1.9%) subsequently tested positive. Eleven cases with an initial negative SARS-CoV-2 test and without a known prior positive SARS-CoV-2 test were reviewed; 6 were employed as healthcare workers and 10 were positive on the second test.
We found a low diagnostic yield of repeat testing for SARS-CoV-2 in our health system. Repeat testing might prove useful in certain clinical scenarios, such as in healthcare workers, when symptoms develop after a negative test, and in hospitalized patients with a high clinical suspicion for COVID-19.
确定 SARS-CoV-2 重复检测的诊断收益。
对 2020 年 3 月 9 日至 4 月 29 日期间在加州大学洛杉矶分校卫生系统内进行的所有 SARS-CoV-2 检测结果进行回顾性分析。确定所有具有重复检测结果的患者，并对具有不一致结果的患者进行了审查。
在 3 月 9 日至 4 月 29 日期间，有 10165 例 SARS-CoV-2 检测结果，其中 630 例（6.2%）呈阳性。在 904 例具有重复检测结果的患者中，808 例（89.4%）最初为阴性，96 例（10.6%）最初为阳性。在最初为阴性的 808 例患者中，有 15 例（1.9%）随后检测为阳性。对 11 例最初 SARS-CoV-2 检测为阴性且无已知先前 SARS-CoV-2 检测阳性的病例进行了审查；其中 6 例是医护人员，10 例在第二次检测中呈阳性。
我们发现我们的卫生系统中 SARS-CoV-2 重复检测的诊断收益较低。重复检测可能在某些临床情况下证明有用，例如在症状出现在阴性检测之后的医护人员中，以及在 COVID-19 临床高度疑似的住院患者中。
