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手术与非手术治疗阻塞性睡眠呼吸暂停低通气综合征。

Surgical versus non-surgical treatment in the Obstructive Sleep Apnea-Hypopnea Syndrome.

机构信息

ENT Department, Hospital Universitario Doctor Peset, Avenida Gaspar Aguilar, Nº 90, Valencia, Spain.

ENT Department, Hospital Universitari General de Catalunya, San Cugat Del Vallès, Barcelona, Spain; Universitat Internacional de Catalunya, Calle Josep Trueta, s/n, San Cugat Del Vallès, Barcelona, Spain.

出版信息

Int J Pediatr Otorhinolaryngol. 2020 Nov;138:110310. doi: 10.1016/j.ijporl.2020.110310. Epub 2020 Aug 12.

Abstract

INTRODUCTION

The treatment of choice for pediatric OSAHS is surgical. However, its etiopathogenesis is multifactorial and surgery does not always solve it. Therefore, other modalities of treatment are used. The main objective of this study is to shed light on the efficacy of surgery compared to other treatments.

METHODS AND MATERIALS

Prospective cohort study with 317 children ages 1-13 years and apnea-hypopnea index (AHI) ≥3/h with no previous treatment. The treatment was organised into 3 categories: surgical (n = 201), medical (n = 75) and observation (n = 41). Quality of life and sleep was assessed by two validated questionnaires (PSQ & Esteller et al.) The upper airway was explored, and nocturnal polysomnography (PSG) performed in every patient. After 12 ± 3 months of treatment was completed, a new PSG and questionnaires were evaluated.

RESULTS

The surgical group improved significantly both subjectively and objectively. Mean AHI decreased from 7.95/h to 2.57/h and T 90 (time spent with arterial oxygen saturation <90%) from 0.49 to 0. AHI of the medical group decreased only from 5.09/h to 4.9/h. Subjective parameters improved less than in the surgical group. Persistence after surgery was 31%, 50% following medical treatment, and after observation 75%. There were no differences in age and BMI between groups. Age or obesity showed no relationship with treatment success or failure.

CONCLUSIONS

The best results were achieved in surgically treated children. However, 31% of those operated had OSAHS persistence, which means a combination of treatments may be the most appropriate strategy.

摘要

简介

小儿 OSAHS 的治疗选择是手术。然而,其病因是多因素的,手术并不总是能解决问题。因此,会采用其他治疗方法。本研究的主要目的是阐明手术与其他治疗方法相比的疗效。

方法和材料

这是一项前瞻性队列研究,纳入了 317 名年龄在 1-13 岁之间、呼吸暂停-低通气指数(AHI)≥3/h 且无既往治疗的儿童。将治疗分为 3 类:手术(n=201)、药物(n=75)和观察(n=41)。使用两个经过验证的问卷(PSQ 和 Esteller 等人)评估生活质量和睡眠。对每个患者进行上气道检查和夜间多导睡眠图(PSG)。在完成 12±3 个月的治疗后,评估新的 PSG 和问卷。

结果

手术组在主观和客观方面均有显著改善。平均 AHI 从 7.95/h 降至 2.57/h,T90(动脉血氧饱和度<90%的时间)从 0.49 降至 0。药物组的 AHI 仅从 5.09/h 降至 4.9/h。主观参数的改善小于手术组。手术后的持续率为 31%,药物治疗后为 50%,观察后为 75%。各组间的年龄和 BMI 无差异。年龄或肥胖与治疗成功或失败无关。

结论

手术治疗的儿童效果最好。然而,31%接受手术治疗的儿童仍存在 OSAHS,这意味着联合治疗可能是最合适的策略。

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