Liu Rongyue, Kong Xiangdong
Department of Otolaryngology, The First People's Hospital of Fuyang Hangzhou, Hangzhou 311400, Zhejiang, China.
Department of Nephrology, The First People's Hospital of Fuyang Hangzhou, Hangzhou 311400, Zhejiang, China.
Emerg Med Int. 2022 Jun 16;2022:9536617. doi: 10.1155/2022/9536617. eCollection 2022.
To study the changes of liver and kidney function-related indexes in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and analyze their clinical significance.
Ninety OSAHS patients treated in our hospital from April 2019 to April 2021 were selected. According to the apnea-hypopnea Index (AHI), they were divided into mild OSAHS group (5 ≤ AHI < 15 times/h, 35 people), moderate OSAHS group (15 ≤ AHI < 30 times/h, 35 people), and severe OSAHS group (AHI ≥ 30 times/h, 20 people). In addition, 50 healthy people who underwent physical examination in our hospital at the same time were selected as the control group, and the liver and kidney function and polysomnography (PSG)-related indexes of the above subjects were detected, and the comparison between the groups was carried out.
The serum BUN and SCR levels of the severe group were significantly higher than those of the moderate group, the moderate group had significantly higher levels than the mild group, and the mild group had significantly higher levels than the control group ( < 0.05). The blood AST level of the severe group was significantly lower than that of the moderate group, the moderate group had a significantly lower level than the mild group, and the mild group had a significantly lower level than the control group ( < 0.05). The blood ALT level of the severe group was significantly higher than that of the moderate group, the moderate group had significantly a higher level than the mild group, and the mild group had a significantly higher level than the control group ( < 0.05). The proportions of abnormal liver and kidney function in the control group, mild group, moderate group, and severe group were significantly different ( < 0.05). The AHI of the severe group was significantly higher than that of the moderate group, the moderate group had a higher value than the mild group, and the mild group had a higher value than the control group ( < 0.05). The ASpO and MSpO of the severe group were significantly lower than those of the moderate group, the moderate group had significantly lower values than the mild group, and the mild group had significantly lower values than the control group ( < 0.05). Spearman correlation analysis showed that the liver and kidney function indexes of OSAHS patients were significantly correlated with PSG indexes ( < 0.05).
Patients with OSAHS will have obvious liver and kidney dysfunction, and the monitoring of liver and kidney function in such patients should be strengthened. If abnormality occurs, early intervention is recommended.
研究阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者肝肾功能相关指标的变化并分析其临床意义。
选取2019年4月至2021年4月在我院治疗的90例OSAHS患者。根据呼吸暂停低通气指数（AHI），将其分为轻度OSAHS组（5≤AHI＜15次/小时，35人）、中度OSAHS组（15≤AHI＜30次/小时，35人）和重度OSAHS组（AHI≥30次/小时，20人）。此外，选取同期在我院进行体检的50例健康人作为对照组，检测上述对象的肝肾功能及多导睡眠图（PSG）相关指标，并进行组间比较。
重度组血清尿素氮（BUN）和血肌酐（SCR）水平显著高于中度组，中度组显著高于轻度组，轻度组显著高于对照组（P＜0.05）。重度组血谷草转氨酶（AST）水平显著低于中度组，中度组显著低于轻度组，轻度组显著低于对照组（P＜0.05）。重度组血谷丙转氨酶（ALT）水平显著高于中度组，中度组显著高于轻度组，轻度组显著高于对照组（P＜0.05）。对照组、轻度组、中度组和重度组肝肾功能异常比例差异有统计学意义（P＜0.05）。重度组AHI显著高于中度组，中度组高于轻度组，轻度组高于对照组（P＜0.05）。重度组最低血氧饱和度（ASpO）和平均血氧饱和度（MSpO）显著低于中度组，中度组显著低于轻度组，轻度组显著低于对照组（P＜0.05）。Spearman相关性分析显示，OSAHS患者肝肾功能指标与PSG指标显著相关（P＜0.05）。
OSAHS患者会出现明显的肝肾功能障碍，对此类患者应加强肝肾功能监测。若出现异常，建议早期干预。
