从腹泻成人中分离出的大肠杆菌产肠毒素能力丧失模式：与血清型相互关系的提示性证据
Patterns of loss of enterotoxigenicity by Escherichia coli isolated from adults with diarrhea: suggestive evidence for an interrelationship with serotype.
作者信息
Evans D J, Evans D G, DuPont H L, Orskov F, Orskov I
出版信息
Infect Immun. 1977 Jul;17(1):105-11. doi: 10.1128/iai.17.1.105-111.1977.
Abstract
Enterotoxigenic Escherichia coli isolates obtained in Mexico from adult subjects with diarrhea and from healthy controls were examined for the production of heat-stable enterotoxin (ST) and heat-labile enterotoxin (LT) after serial passage in the laboratory. Isolates were found to be either stable for the production of ST and LT or unstable with respect to ST, LT, or both. Unilateral loss of either ST or LT production allowed classification of E. coli isolates into four groups according to stability/instability of enterotoxin production. Fewer serotypes, with more representative isolates, were in group I (stable) than in group IV (completely unstable). Isolates from Dacca, Bangladesh, could be similarly classified into stability groups. There is an apparent relationship between serotype, stability of enterotoxin production, particularly LT, and isolation from diarrhea cases as opposed to isolation from healthy controls.
摘要
对从墨西哥患有腹泻的成人受试者和健康对照者中分离出的产肠毒素大肠杆菌菌株在实验室连续传代后，检测其热稳定肠毒素（ST）和热不稳定肠毒素（LT）的产生情况。发现这些菌株要么ST和LT产生稳定，要么ST、LT或两者产生不稳定。ST或LT产生的单方面丧失使大肠杆菌菌株可根据肠毒素产生的稳定性/不稳定性分为四组。与第四组（完全不稳定）相比，第一组（稳定）中的血清型较少，但有更多代表性菌株。来自孟加拉国达卡的菌株也可类似地分为稳定性组。血清型、肠毒素产生的稳定性，尤其是LT的稳定性，与从腹泻病例中分离而非从健康对照中分离之间存在明显关系。
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