iPSCs 衍生平台：探究 SARS-CoV-2 嗜神经性的可行工具。
iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2.
机构信息
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P. R. China.
Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 110 Xiangya Road, Changsha 410078, P. R. China.
出版信息
ACS Chem Neurosci. 2020 Sep 2;11(17):2489-2491. doi: 10.1021/acschemneuro.0c00512. Epub 2020 Aug 25.
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a severe public health problem with a high rate of morbidity and mortality. A mounting number of clinical investigations illustrate that COVID-19 patients suffer from neurologic conditions in addition to respiratory symptoms. In a recent article, Yuen and colleagues present the first experimental evidence of SARS-CoV-2 infection in the human central nervous system using induced pluripotent stem cells (iPSCs)-derived platform including human neural progenitor cells, neurospheres, and three-dimensional brain organoids (Yuen, K.Y., and Huang, J.D. et al. (2020) DOI: 10.1038/s41422-020-0390-x).
新型严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）已成为一个严重的公共卫生问题，其发病率和死亡率都很高。越来越多的临床研究表明，COVID-19 患者除了呼吸系统症状外，还患有神经系统疾病。在最近的一篇文章中，Yuen 及其同事使用诱导多能干细胞（iPSC）衍生的平台，包括人神经祖细胞、神经球和三维脑类器官，提供了 SARS-CoV-2 感染人类中枢神经系统的首个实验证据（Yuen，K.Y.，和 Huang，J.D.等人（2020）DOI：10.1038/s41422-020-0390-x）。
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