Calabrese Cecilia, Annunziata Anna, Mariniello Domenica Francesca, Coppola Antonietta, Mirizzi Angela Irene, Simioli Francesca, Pelaia Corrado, Atripaldi Lidia, Pugliese Gaia, Guarino Salvatore, Fiorentino Giuseppe
Department of Translational Medical Sciences, University of Campania 'Luigi Vanvitelli', A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
Department of Intensive Care, A.O.R.N. Ospedali dei Colli, 80131 Napoli, Italy.
Pathogens. 2022 Jul 14;11(7):793. doi: 10.3390/pathogens11070793.
The vaccination campaign and the new SARS-CoV-2 variants may have changed the clinical profile and outcomes of patients admitted to sub-intensive unit care. We conducted a retrospective study aimed to compare the clinical and radiological features of unvaccinated critical COVID-19 patients hospitalized during the last pandemic wave (December 2021−February 2022, No-Vax group) and before starting the vaccination campaign (March−December 2020, Pre-Vax group). The No-Vax group was also compared with vaccinated patients of the same pandemic wave (Vax group). With respect to the Pre-Vax group, the No-Vax group contained a higher percentage of smokers (p = 0.0007) and a lower prevalence of males (p = 0.0003). At admission, the No-Vax patients showed both a higher CT score of pneumonia and a worse severe respiratory failure (p < 0.0001). In the No-Vax group, a higher percentage of deaths occurred, though this was not significant. In comparison with the No-Vax group, the Vax patients were older (p = 0.0097), with a higher Charlson comorbidity index (p < 0.0001) and a significantly lower HRCT score (p = 0.0015). The percentage of deaths was not different between the two groups. The No-Vax patients showed a more severe disease in comparison with the Pre-Vax patients, and were younger and had fewer comorbidities than the Vax patients.
疫苗接种运动和新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体可能改变了入住亚重症监护病房患者的临床特征和治疗结果。我们进行了一项回顾性研究，旨在比较在最后一波疫情期间（2021年12月至2022年2月，未接种疫苗组）以及在疫苗接种运动开始前（2020年3月至12月，接种疫苗前组）住院的未接种疫苗的重症冠状病毒病2019（COVID-19）患者的临床和影像学特征。未接种疫苗组还与同一波疫情中的接种疫苗患者（接种疫苗组）进行了比较。与接种疫苗前组相比，未接种疫苗组吸烟者的比例更高（p = 0.0007），男性患病率更低（p = 0.0003）。入院时，未接种疫苗的患者肺炎CT评分更高，严重呼吸衰竭情况更差（p < 0.0001）。在未接种疫苗组中，死亡百分比更高，尽管差异不显著。与未接种疫苗组相比，接种疫苗的患者年龄更大（p = 0.0097），查尔森合并症指数更高（p < 0.0001），高分辨率计算机断层扫描（HRCT）评分显著更低（p = 0.0015）。两组之间的死亡百分比没有差异。与接种疫苗前的患者相比，未接种疫苗的患者疾病更严重，且比接种疫苗的患者更年轻，合并症更少。
