Zhuang Y L, Zhang Y T, Li M, Luo M, Zhu Z H, Tan X H, Yi Y, Chen X G, Deng A P, Zheng H Z, Kang M, Song T, Sun L M
Institute of Infectious Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
Institute of Environment and School Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Jul 6;54(7):720-725. doi: 10.3760/cma.j.cn112150-20200326-00446.
Analysis of clustering characteristics of coronavirus disease 2019 (COVID-19) in Guangdong Province. The COVID-19 cases in Guangdong Province onset from January 1 to February 29, 2020 were collected from Chinese information system for disease control and prevention and Emergency Public Reporting System. Obtain the epidemiological survey data of the cluster epidemic situation, and clarify the scale of cluster epidemic situation, the characteristics of the index cases, family and non-family subsequent cases. Calculate serial interval according to the onset time of the index cases and subsequent cases, secondary attack rate based on the close contacts tracking results, the characteristics of different cases in the clustered epidemic were compared. A total of 283 cluster were collected, including 633 index cases, 239 subsequent cases. Families are mainly clustered, the total number involved in each cluster is in the range of 2-27, (, ) are 2.0 (2.0, 4.0). During January 15 to February 29, the secondary attack rate is 2.86% (239/8 363) in Guangdong Province, the family secondary attack rate was 4.84% (276/3 697), and the non-family secondary attack rate was 1.32% (61/4 632). According to the reporting trend of the number of cases in Guangdong Province, it can be divided into four stages, the rising stage, the high platform stage, the descending stage and the low level fluctuation period. The secondary attack rate of the four stages were 3.5% (140/3 987), 2.3% (55/2 399), 2.6% (37/1 435), 1.3% (7/542), respectively. The difference was statistically significant (=0.003). COVID-19 cluster mainly occurs in families in Guangdong Province. The scale of the clustered epidemic was small; the serial interval was short; and the overall secondary attack rate was low.
广东省新型冠状病毒肺炎(COVID-19)聚集性特征分析。收集2020年1月1日至2月29日广东省发病的COVID-19病例,来源于中国疾病预防控制信息系统和突发公共卫生事件报告系统。获取聚集性疫情的流行病学调查数据,明确聚集性疫情规模、指示病例、家庭续发病例和非家庭续发病例特征。根据指示病例与续发病例发病时间计算代间距,依据密切接触者追踪结果计算二代发病率,比较聚集性疫情中不同病例特征。共收集到283起聚集性疫情,包括633例指示病例、239例续发病例。以家庭聚集为主,每起聚集性疫情涉及总人数在2至27人之间,(,)为2.0(2.0,4.0)。1月15日至2月29日,广东省二代发病率为2.86%(239/8363),家庭二代发病率为4.84%(276/3697),非家庭二代发病率为1.32%(61/4632)。根据广东省病例报告趋势,可分为四个阶段,即上升期、平台期、下降期和低水平波动期。四个阶段的二代发病率分别为3.5%(140/3987)、2.3%(55/2399)、2.6%(37/1435)、1.3%(7/542),差异有统计学意义(=0.003)。广东省COVID-19聚集性疫情主要发生在家庭中。聚集性疫情规模小;代间距短;总体二代发病率低。