Yan T L, Xia J, Xu J Y, Zheng P, Zhou S P, Chen T, Jia G
Department of Occupational and Environmental Health Sciences, Peking University of School of Public Health, Beijing 100191, China.
Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Jul 6;54(7):774-778. doi: 10.3760/cma.j.cn112150-20200508-00699.
To evaluate the effects of exposure of fine particle matter (PM) and ozone (O) in Beijing as the main pollutants on olfaction of SD rats. In October 16, 2018, twenty 8-week-old SD rats were randomly divided into two groups, 10 rats in the exposure group and 10 rats in the control group. They were fed in air pollutant exposure system and clean experimental environment respectively, and the concentrations of PM and O in each system were measured. The degree of olfaction damage of SD rats at different feeding time was assessed by using the buried food test (BFT). The difference of BFT time between the two groups was analyzed by performing the repeated measures analysis of variance. The results showed that the concentrations of PM and O in the exposure group were (22.65±11.47) μg/m and (12.36±5.87) μg/m, respectively, while those in the control group were both 0 μg/m. The repeated measures analysis of variance showed that the time of BFT in the exposure group was longer than that in the control group (=6.49, =0.031). With the increase of feeding time, the time of BFT was prolonged (=61.69, <0.001). Exposure to PM and O in the atmosphere might lead to olfaction damage in rats.
评估北京地区以细颗粒物（PM）和臭氧（O）为主要污染物的暴露对SD大鼠嗅觉的影响。2018年10月16日，将20只8周龄的SD大鼠随机分为两组，暴露组10只，对照组10只。分别在空气污染物暴露系统和清洁实验环境中饲养，测定各系统中PM和O的浓度。采用埋食试验（BFT）评估不同饲养时间SD大鼠的嗅觉损伤程度。通过重复测量方差分析两组BFT时间的差异。结果显示，暴露组中PM和O的浓度分别为（22.65±11.47）μg/m和（12.36±5.87）μg/m，而对照组均为0μg/m。重复测量方差分析显示，暴露组的BFT时间长于对照组（F = 6.49，P = 0.031）。随着饲养时间的增加，BFT时间延长（F = 61.69，P < 0.001）。大气中PM和O的暴露可能导致大鼠嗅觉损伤。
