Rojo M Ángeles, Garrosa Manuel, Jiménez Pilar, Girbés Tomás, Garcia-Recio Verónica, Cordoba-Diaz Manuel, Cordoba-Diaz Damián
Area of Experimental Sciences, Miguel de Cervantes European University, 47012 Valladolid, Spain.
Area of Histology, Faculty of Medicine and INCYL, University of Valladolid, 47005 Valladolid, Spain.
Toxins (Basel). 2020 Aug 22;12(9):542. doi: 10.3390/toxins12090542.
The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder ( L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.
浓缩食品补充剂摄入的安全性是一个主要的健康问题。绿茶多酚（GTPs）的食用具有促进健康的作用，这一点已经得到充分证实。然而，由于有不良反应的报道，大量摄入GTPs存在争议。我们对口服标准化浓缩GTPs制剂对小鼠的影响进行了初步探索，这些小鼠因摄入亚致死量的矮接骨木抗核糖体凝集素ebulin f而出现可逆性肠道紊乱。单独口服30mg/kg体重的Polyphenon 60或腹腔注射2.5mg/kg体重的ebulin f均未引发致命毒性。相比之下，同时给予相同剂量的Polyphenon 60和ebulin f会引发一种重要且意想不到的协同毒性作用，其特征是体重呈双相下降，持续8天后体重下降达40%。联合治疗开始2天后出现致死性，10天后致死率超过50%。
