Lowe K C
Department of Zoology, University of Nottingham, U.K.
Adv Exp Med Biol. 1988;222:655-63. doi: 10.1007/978-1-4615-9510-6_81.
Data from both in vivo and in vitro studies to assess lymphoid tissue and immune system responses to emulsified PFCs and their components have been discussed. It may be concluded that the extent to which PFC emulsions are retained in lymphoid tissues and their effects on the manifestation of humoral immune responses to immunological "challenges" is variable and depends upon: (1) Emulsion composition; (2) Dose administered; (3) Route of administration; (4) Tissue examined; (5) Timing of emulsion administration relative to immune challenge; and (6) Species studied. Such variability in the responses to emulsified PFCs has inevitably introduced difficulties in assessing their effects upon immunological competence. Further work is needed determine the extent to which lymphoid tissue functions may be altered by PFC emulsions and identify the active component(s) and mechanism(s) involved.
已对评估乳化全氟化合物及其成分对淋巴组织和免疫系统反应的体内和体外研究数据进行了讨论。可以得出结论，全氟化合物乳液在淋巴组织中的留存程度及其对免疫“刺激”引起的体液免疫反应表现的影响是可变的，并且取决于：（1）乳液成分；（2）给药剂量；（3）给药途径；（4）检查的组织；（5）乳液给药相对于免疫刺激的时间；以及（6）所研究的物种。对乳化全氟化合物反应的这种变异性不可避免地给评估它们对免疫能力的影响带来了困难。需要进一步开展工作，以确定全氟化合物乳液可能改变淋巴组织功能的程度，并确定其中的活性成分和相关机制。
