Wang Liuyuan, Yang Bin, Tso Lai S, Zhao Peizhen, Ke Wujian, Zhang Xiaohui, Chen Zhengyu, Ren Xuqi, Liang Chunmei, Liao Yuying, Chen Huiru, Huang Jinmei, Yang Ligang
Department of Dermatology and Venerology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Department of Venerology, Dermatology Hospital, Southern Medical University, Guangzhou, China.
Int J STD AIDS. 2020 Oct;31(11):1073-1081. doi: 10.1177/0956462419890496. Epub 2020 Aug 25.
Prevalence of co-infecting sexually transmitted infections (STIs) among patients newly diagnosed with anogenital warts is under-reported. Our objective is to determine the prevalence of six common STIs, (CT), (NG), (MG), genital herpes (herpes simplex virus type 2 [HSV-2]), HIV, and syphilis for patients visiting a sexual health clinic in Guangzhou, China. Demographics, sexual health, and medical histories were collected at patient intake. Patients diagnosed with anogenital warts (N = 200) were invited to participate. We collected urine samples, and urethral, cervical, and rectal swabs to test for CT, NG, and MG, and blood samples for serological detection of HSV-2, syphilis, and HIV. Overall 49 (24.5%) had a co-infection (22.2% of men and 27.7% of women). All six STIs were observed among men: CT (6.8%), NG (3.4%), MG (5.1%), HIV (4.3%), HSV-2 (4.3%), and syphilis (1.7%). Women had fewer STIs, but at higher rates: CT (13.3%), MG (6.0%), and HSV-2 (8.4%). Individual men had up to two co-infections, while women had no more than one co-infection. Chlamydia was the most common STI. Patients aged 18-25 years (35.4%) had the highest prevalence. Although opportunistic screening is often applied for high-risk groups, expansion to patients with anogenital warts in all health-care settings would improve detection of problematic asymptomatic co-infections, thereby increasing China's capacity to contribute toward global surveillance systems.
新诊断为肛门生殖器疣的患者中同时感染性传播感染（STIs）的情况报告不足。我们的目标是确定在中国广州一家性健康诊所就诊的患者中六种常见性传播感染的患病率，即沙眼衣原体（CT）、淋病奈瑟菌（NG）、生殖支原体（MG）、生殖器疱疹（单纯疱疹病毒2型[HSV-2]）、HIV和梅毒。在患者就诊时收集人口统计学、性健康和病史信息。邀请诊断为肛门生殖器疣的患者（N = 200）参与。我们收集尿液样本、尿道拭子、宫颈拭子和直肠拭子以检测CT、NG和MG，并收集血液样本用于HSV-2、梅毒和HIV的血清学检测。总体而言，49例（24.5%）存在合并感染（男性为22.2%，女性为27.7%）。在男性中观察到了所有六种性传播感染：CT（6.8%）、NG（3.4%）、MG（5.1%）、HIV（4.3%）、HSV-2（4.3%）和梅毒（1.7%）。女性的性传播感染种类较少，但感染率较高：CT（13.3%）、MG（6.0%）和HSV-2（8.4%）。男性个体最多有两种合并感染，而女性不超过一种合并感染。衣原体是最常见的性传播感染。18至25岁的患者患病率最高（35.4%）。尽管机会性筛查通常应用于高危人群，但在所有医疗机构中将筛查范围扩大到肛门生殖器疣患者将改善对无症状合并感染问题的检测，从而提高中国对全球监测系统的贡献能力。
