Sullivan J M, Prewitt R L, Ratts T E
Department of Medicine, University of Tennessee, Memphis 38163.
Am J Med Sci. 1988 Apr;295(4):370-7. doi: 10.1097/00000441-198804000-00025.
The responses to sodium depletion and repletion were studied in subgroups of 92 normotensive and 65 borderline hypertensive individuals. The borderline hypertensives were characterized by significantly higher blood pressure, weight, cardiac output, hematocrit and decreased density of conjunctival capillaries and venules. Sodium-sensitivity was defined as an increase in mean arterial blood pressure exceeding 5% during sodium repletion. The prevalence of sodium-sensitivity was higher in blacks than in whites and greater in hypertensives than in normotensives. Sodium-sensitive individuals were characterized by significantly increased forearm vascular resistance and decreased plasma renin activity and aldosterone concentration. The resemblance of these changes to those reported in the Dahl salt-sensitive rat suggests a genetic basis for the response to sodium.
在92名血压正常者和65名临界高血压个体的亚组中研究了对钠缺失和补充的反应。临界高血压患者的特征是血压、体重、心输出量、血细胞比容显著升高，结膜毛细血管和小静脉密度降低。钠敏感性定义为钠补充期间平均动脉血压升高超过5%。黑人中钠敏感性的患病率高于白人，高血压患者高于血压正常者。钠敏感个体的特征是前臂血管阻力显著增加，血浆肾素活性和醛固酮浓度降低。这些变化与Dahl盐敏感大鼠中报道的变化相似，提示对钠反应存在遗传基础。
