Department of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R907-R914. doi: 10.1152/ajpregu.00399.2017. Epub 2018 Aug 22.
High blood pressure affects 1.39 billion adults across the globe and is the leading preventable cause of death worldwide. Hypertension is a multifaceted disease with known genetic and environmental factors contributing to its progression. Our studies utilizing the Dahl salt-sensitive (SS) rat have demonstrated the remarkable influence of dietary protein and maternal environment on the development of hypertension and renal damage in response to high salt. There is growing interest in the relationship between the microbiome and hypertension, with gut dysbiosis being correlated to a number of pathologies. This review summarizes the current literature regarding the interplay among dietary protein, the gut microbiota, and hypertension. These studies may provide insight into the effects we have observed between diet and hypertension in Dahl SS rats and, we hope, lead to new perspectives where potential dietary interventions or microbiota manipulations could serve as plausible therapies for hypertension.
高血压影响全球 13.9 亿成年人，是全球可预防的主要死因。高血压是一种多方面的疾病，已知遗传和环境因素与其发展有关。我们利用达尔盐敏感（SS）大鼠的研究表明，饮食蛋白和母体环境对高血压和高盐引起的肾脏损伤的发展有显著影响。人们对微生物组与高血压之间的关系越来越感兴趣，肠道菌群失调与许多病理有关。这篇综述总结了目前关于饮食蛋白、肠道微生物群和高血压之间相互作用的文献。这些研究可能有助于我们了解达尔 SS 大鼠饮食和高血压之间的关系，并希望为新的观点提供依据，即潜在的饮食干预或微生物群操作可能成为高血压的合理治疗方法。
