Cornea & External Diseases Service, Moorfields Eye Hospital, 162 City Road, London, EC1V 2PD, UK.
NIHR Moorfields Clinical Research Facility, Moorfields Eye Hospital, London, UK.
Eye (Lond). 2020 Dec;34(12):2219-2226. doi: 10.1038/s41433-020-01153-x. Epub 2020 Aug 25.
Herpes simplex keratitis (HSK) is a common, potentially blinding condition characterised by recurrent infections of the cornea, seen by both general ophthalmologists and corneal specialists. Successful treatment of recurrences reduces disease duration, prevents progressive corneal scaring leading to vision loss and reduces risk of further recurrences. In this review we discuss the relative advantages of the diagnostic laboratory investigations including polymerase chain reaction, viral culture and fluorescence-based immunohistochemistry. We review treatment strategies in selected aspects of HSK and discuss the management options in cases not responding to treatment.
单纯疱疹病毒性角膜炎（HSK）是一种常见的、潜在致盲性疾病，其特征为角膜反复感染，可由普通眼科医生和角膜专家共同诊断。成功治疗复发可缩短疾病持续时间，防止进行性角膜瘢痕导致视力丧失，并降低进一步复发的风险。在本综述中，我们讨论了包括聚合酶链反应、病毒培养和基于荧光的免疫组织化学在内的诊断实验室检查的相对优势。我们回顾了 HSK 某些方面的治疗策略，并讨论了治疗无效病例的处理选择。
