Department of Biochemistry, University of Iowa College of Medicine, Iowa City, IA, USA.
Nat Struct Mol Biol. 2020 Oct;27(10):1-2. doi: 10.1038/s41594-020-0502-9.
During translesion synthesis, eukaryotic DNA polymerase ζ (zeta) carries out extension from a wide range of DNA lesions. In this issue, Malik et al. (2020) (1) present the cryo-EM structure of polymerase ζ and show how it catalyzes the extension step of translesion synthesis.
在跨损伤合成过程中，真核 DNA 聚合酶 ζ（zeta）可以从多种 DNA 损伤部位进行延伸。在本期杂志中，Malik 等人（2020）（1）展示了聚合酶 ζ 的冷冻电镜结构，并说明了它如何催化跨损伤合成的延伸步骤。
