Asseman P, Pruvost P, Lesenne M, Adnet P, Leroy F, Vigne J M, Delvallez L, Lacroix D, Thery C
Service de Soins intensifs, Hôpital Cardiologique, Lille.
Ann Cardiol Angeiol (Paris). 1988 Mar;37(3):153-61.
The first results of the long-term treatment of chronic heart failure with inotrope positive medications are disappointing, especially in that survival is not prolonged and even a greater mortality is suggested. Is it because of the regular failure of specific medications, of a class of medications or because the overall concept of inotropism stimulation during chronic heart failure should be condemned? The mechanisms of inotropism of normal muscles or muscles in human chronic heart failure are reviewed as well as the various pharmacological means available to stimulate inotropism.
使用正性肌力药物长期治疗慢性心力衰竭的初步结果令人失望，尤其是生存率并未延长，甚至提示死亡率更高。这是因为特定药物、某一类药物经常失效，还是因为慢性心力衰竭期间正性肌力刺激的整体概念应受到谴责？本文综述了正常肌肉或人类慢性心力衰竭肌肉的正性肌力机制，以及可用于刺激正性肌力的各种药理学方法。
