Hajjej Abdelhafidh, Abdrakhmanova Saniya, Turganbekova Aida, Almawi Wassim Y
Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia.
Research and Production Center of Transfusion, Kazakhstan Ministry of Health, Astana, Kazakhstan.
HLA. 2020 Nov;96(5):615-620. doi: 10.1111/tan.14057. Epub 2020 Sep 10.
HLA profiles of German and Uzbek minorities in Kazakhstan were analyzed and were compared with other populations. In total, 107 and 119 HLA alleles were identified in Germans and Uzbeks, respectively. A02:01 (25.49%), B07:02 (9.80%), B08:01 (9.80%), C07:02 (13.46%), DRB107:01 (21.57%), and DQB103:01 (25%) were frequent among Germans, while A02:01 (17.86%), B07:02 (8.33%), C04:01 (15%), DRB107:01 (13.09%), and DQB103:01 (20%) were common alleles in Uzbeks. A03:01 ~ B07:02 ~ C07:02 ~ DRB115:01 ~ DQB106:02 (6%) and A24:02 ~ B38:01 ~ C12:03 ~ DRB114:01 ~ DQB1*05:03 (3.75%) were the most frequent five-locus haplotypes in Germans and Uzbeks, respectively. Germans of Kazakhstan are genetically related to European Russians, Germans and Eastern Europeans, suggesting their European Russia (Volga Region) origin following their 19th century migration to central Asia. Uzbeks, likely indigenous, were genetically close to Eastern Russians, Europeans, and Asians.
对哈萨克斯坦的德国和乌兹别克少数民族的人类白细胞抗原（HLA）谱进行了分析，并与其他人群进行了比较。德国人中总共鉴定出107个HLA等位基因，乌兹别克人中有119个。A02:01（25.49%）、B07:02（9.80%）、B08:01（9.80%）、C07:02（13.46%）、DRB107:01（21.57%）和DQB103:01（25%）在德国人中较为常见，而A02:01（17.86%）、B07:02（8.33%）、C04:01（15%）、DRB107:01（13.09%）和DQB103:01（20%）是乌兹别克人中的常见等位基因。A03:01B*07:02C07:02~DRB115:01DQB106:02（6%）和A24:02B38:01~C12:03DRB1*14:01DQB1*05:03（3.75%）分别是德国人和乌兹别克人中最常见的五位单倍型。哈萨克斯坦的德国人在基因上与俄罗斯欧洲人、德国人以及东欧人相关，这表明他们在19世纪迁移到中亚后起源于俄罗斯欧洲部分（伏尔加地区）。可能是本土居民的乌兹别克人在基因上与俄罗斯东部人、欧洲人和亚洲人接近。
